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Guidelines

MIRAGE

cytochrome P450 family 3 subfamily A member 4

Summary

Gene Symbol

CYP3A4

Organism

Saimiri boliviensis (Bolivian squirrel monkey)

External Links

NCBI Gene: 101037403
KEGG Gene ID: sbq:101037403
PubChem: 101037403

Annotation

Keyword

Heme
Microsome
Monooxygenase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q0PPV0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
steroid metabolic process	IEA	30032202
oxidative demethylation	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

demethylation [inference]

oxidative demethylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
iron ion binding	IEA	22301074
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA	22301074
heme binding	IEA	22301074
testosterone 6-beta-hydroxylase activity	IEA	30032202
estrogen 16-alpha-hydroxylase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

steroid hydroxylase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K17689

Name

cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]

References

Ortholog

Displaying entries **1 - 10** of **125** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1576		HUMAN90182
Bos taurus	282214		BOVIN20916
Sus scrofa	403324		PIGXX20288
Canis lupus familiaris	415127		CANLF16239
Canis lupus familiaris	415129		CANLF16239
Pan troglodytes	463582		PANTR40887
Canis lupus familiaris	479740		CANLF16240
Bos taurus	507988		BOVIN20918
Bos taurus	517246		BOVIN20921
Bos taurus	526682		BOVIN20920

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025