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Standards Ontologies Notations
phospholipase C gamma 2

Summary
Gene Symbol
  • PLCG2
Organism
Odobenus rosmarus divergens (Pacific walrus)
NCBI Gene
101378505
KEGG Gene ID
oro:101378505
PubChem
101378505
Annotation
Keyword
  • Calcium
  • Hydrolase
  • Lipid degradation
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • SH2 domain
  • SH3 domain
  • Transducer
Proteins
Displaying 1 entry
UniProt Protein Name
A0A2U3VC63
Annotation information from UniProt.
Gene Ontology (GO)
Displaying all 3 entries
GO Term Evidence Code PMID
phosphatidylinositol-mediated signaling
phospholipid catabolic process
positive regulation of epithelial cell migration
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Carnivora
Group Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Functional Category
  • K: Transcription
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
Displaying all 7 entries
Gene Ontology
hydrolase activity
lipid metabolic process
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
phospholipid catabolic process
positive regulation of epithelial cell migration
release of sequestered calcium ion into cytosol
Displaying entries 1 - 10 of 17 in total
InterPro
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain
C2 domain superfamily
C2 domain
EF-hand domain pair
PH-like domain superfamily
PLC-gamma, C-terminal SH2 domain
PLC-gamma, N-terminal SH2 domain
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
Phosphatidylinositol-specific phospholipase C, X domain
KEGG BRITE Database
Orthology
K05859
Name
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
References
Rhea

RHEA:33179

H2O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
H+ + a 1,2-diacyl-sn-glycerol + 1D-myo-inositol 1,4,5-trisphosphate
Enzyme
PMID
Ortholog
Displaying entries 1 - 10 of 43 in total
Species Gene ID OrthoDB Alliance of Genome Resources Orthologous MAtrix
489692 9615_1:000f14
100481994 9646_0:003353
101080675 9685_0:00458b
101670617 9669_0:000d16
102963653 9694_0:00432c
103662093 29073_0:001cba
106984018 32536_0:002d98
109245637 9691_0:0021f4
110593864 29088_0:0044e2
111152978 391180_0:0029d4
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024