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adhesion G protein-coupled receptor G2

Summary

Gene Symbol

ADGRG2

Organism

Homo sapiens (human)

External Links

NCBI Gene

10149

PubChem

10149

Alliance of Genome Resources

HGNC:4516

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q8IZP9	G-protein coupled receptor 64 Human epididymis-specific protein 6
Q499H0
A8K4P7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cell surface receptor signaling pathway	IEA
G protein-coupled receptor signaling pathway	TAS	9150425
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
spermatogenesis	TAS	9150425

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytosol	IDA
plasma membrane	IDA
plasma membrane	IBA
cell surface	HDA	19581412
membrane	TAS	12420295

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying 1 entry
GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IBA

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G-protein coupled receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
cell surface receptor signaling pathway

Displaying **all 4** entries
InterPro
GAIN domain superfamily
GPCR, family 2, secretin-like
GPCR, family 2-like, 7TM
GPS motif

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111863	X-linked congenital bilateral absence of vas deferens	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 46 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	10149	Xenbase:XB-GENE-17330014
Caenorhabditis elegans	30817	WB:WBGene00017947
Caenorhabditis elegans	64124	WB:WBGene00017947
Caenorhabditis elegans	84873	WB:WBGene00017947
Mus musculus	237175	ZFIN:ZDB-GENE-140106-206	MOUSE65766
Rattus norvegicus	266735	ZFIN:ZDB-GENE-140106-206	RATNO44206
Caenorhabditis elegans	316137	WB:WBGene00017947
Pan troglodytes	465524		PANTR45599
Macaca mulatta	694495		MACMU48610
Equus caballus	100058260		HORSE44171

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Annotation

OrthoDB (Group)

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Acknowledgements