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peptidylglycine alpha-amidating monooxygenase

Summary

Gene Symbol

Pam

Organism

Octodon degus (degu)

External Links

NCBI Gene: 101578434
PubChem: 101578434

Annotation

Keyword

Calcium
Copper
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Lyase
Metal-binding
Monooxygenase
Multifunctional enzyme
Reference proteome
Repeat
Signal
Transmembrane helix
Vitamin C
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A6P3EL60	Cyclin-A/CDK2-associated protein p19 p19skp1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
peptide metabolic process	IEA	22301074
ubiquitin-dependent protein catabolic process	IEA	22301074

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA	22301074
transport vesicle membrane
extracellular region	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IEA	22301074
peptidylamidoglycolate lyase activity
copper ion binding	IEA	22301074
L-ascorbic acid binding
peptidylglycine monooxygenase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [inference]

peptidylglycine monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [inference]

peptidylglycine monooxygenase activity

lyase activity [inference]

carbon-nitrogen lyase activity [inference]

amidine-lyase activity [inference]

peptidylamidoglycolate lyase activity

catalytic activity, acting on a protein [inference]

peptidylamidoglycolate lyase activity

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peptidyl-glycine alpha-amidating monooxygenase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
catalytic activity
lyase activity
metal ion binding
peptide metabolic process
peptidylglycine monooxygenase activity

Displaying **all 3** entries
InterPro
NHL repeat
Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase
Six-bladed beta-propeller, TolB-like

Ortholog

Displaying entries **1 - 10** of 42 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	18484	10090_1:000499
Rattus norvegicus	25508	10116_1:0031d4
Cavia porcellus	100713254	10141_0:000c65
Cricetulus griseus	100770162	10029_0:001285
Jaculus jaculus	101598147	51337_0:003c90
Heterocephalus glaber	101716909	10181_0:000ec5
Mesocricetus auratus	101829991	10036_0:0025b3
Ictidomys tridecemlineatus	101964848	43179_0:003cc9
Microtus ochrogaster	101987160	79684_0:0031de
Chinchilla lanigera	102030078	34839_0:0011ef

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024