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ATPase H+ transporting accessory protein 2

Summary

Gene Symbol

ATP6AP2

Aliases

APT6M8-9
ATP6M8-9
M8-9
PRR
RENR
V-ATPase M8.9 subunit
prorenin receptor
renin receptor

Organism

Homo sapiens (human)

External Links

NCBI Gene

10159

HGNC

18305

KEGG Gene ID

hsa:10159

PubChem

10159

Alliance of Genome Resources

HGNC:18305

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cell projection
Cleavage on pair of basic residues
Congenital disorder of glycosylation
Cytoplasmic vesicle
Disease variant
Endoplasmic reticulum
Endosome
Epilepsy
Intellectual disability
Lysosome
Neurodegeneration
Parkinsonism
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O75787	ATPase H(+)-transporting lysosomal accessory protein 2 ATPase H(+)-transporting lysosomal-interacting protein 2 ER-localized type I transmembrane adapter Embryonic liver differentiation factor 10 N14F Renin/prorenin receptor Vacuolar ATP synthase membrane sector-associated protein M8-9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
lysosomal lumen acidification	IMP NAS	32001091 32276428 33065002
proton transmembrane transport		33065002
Golgi lumen acidification		32001091
synaptic vesicle lumen acidification	IEA
eye pigmentation	IMP	20093472

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification [inference]

rostrocaudal neural tube patterning

developmental process [inference]

anatomical structure morphogenesis [inference]

head morphogenesis

developmental maturation [inference]

anatomical structure maturation [inference]

central nervous system maturation

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction

vacuolar acidification

lysosomal lumen acidification

neuron cellular homeostasis [inference]

synaptic vesicle lumen acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction

vacuolar acidification

lysosomal lumen acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction

vacuolar acidification

lysosomal lumen acidification

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction

vacuolar acidification

lysosomal lumen acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction

vacuolar acidification

lysosomal lumen acidification

pigmentation [inference]

developmental pigmentation [inference]

eye pigmentation

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

establishment of localization in cell [inference]

synaptic vesicle lumen acidification

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction

vacuolar acidification

lysosomal lumen acidification

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta1 production

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

angiotensin maturation

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction

vacuolar acidification

lysosomal lumen acidification

Displaying entries **6 - 10** of 20 in total

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GO Term	Evidence Code	PMID
dendritic spine membrane	IEA
synaptic vesicle membrane	IEA
endosome membrane	ISS NAS	32001091
autophagosome membrane	IEA
Golgi membrane		32001091

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

proton-transporting two-sector ATPase complex [inference]

proton-transporting V-type ATPase complex

vacuolar proton-transporting V-type ATPase complex

proton-transporting two-sector ATPase complex, proton-transporting domain [inference]

proton-transporting V-type ATPase, V0 domain [inference]

vacuolar proton-transporting V-type ATPase, V0 domain

catalytic complex [inference]

ATPase complex [inference]

proton-transporting two-sector ATPase complex [inference]

proton-transporting V-type ATPase complex

vacuolar proton-transporting V-type ATPase complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

secretory granule membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

autophagosome membrane

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

secretory granule membrane [inference]

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

dendritic spine membrane

synaptic membrane [inference]

leading edge membrane [inference]

neuron projection membrane [inference]

dendritic spine membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
signaling receptor activity	IEA
protein binding	IPI	12045255 20093472 29127204 30374053 32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K19514

Name

renin receptor

References

25374826

Disease

The Human Phenotype Ontology

Displaying entries **61 - 70** of 73 in total

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HPO ID	HPO Term
HP:0004313	Decreased circulating antibody level
HP:0006801	Hyperactive deep tendon reflexes
HP:0006956	Lateral ventricle dilatation
HP:0007076	Extrapyramidal muscular rigidity
HP:0007082	Dilated third ventricle
HP:0010527	Astereognosis
HP:0010529	Echolalia
HP:0010819	Atonic seizure
HP:0011448	Ankle clonus
HP:0011812	Agraphesthesia

Displaying **all 5** entries
Disease ID	Disease Name
OMIM:300423	syndromic X-linked intellectual disability Hedera type
ORPHA:93952	syndromic X-linked intellectual disability Hedera type
OMIM:300911	X-linked parkinsonism-spasticity syndrome
ORPHA:363654	X-linked parkinsonism-spasticity syndrome
OMIM:301045	congenital disorder of glycosylation, type IIr

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Tools

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Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

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Acknowledgements