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WASP family member 2

Summary

Gene Symbol

WASF2

Organism

Homo sapiens (human)

External Links

NCBI Gene

10163

PubChem

10163

Alliance of Genome Resources

HGNC:12733

Annotation

Keyword

3D-structure
Actin-binding
Alternative splicing
Cell membrane
Cell projection
Cytoskeleton
Host-virus interaction
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y6W5	Protein WAVE-2 Verprolin homology domain-containing protein 2 Wiskott-Aldrich syndrome protein family member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
actin filament-based movement	IEA
positive regulation of lamellipodium assembly	IMP	18560548 21107423
positive regulation of Arp2/3 complex-mediated actin nucleation	IBA
endocytosis	IEA
megakaryocyte development	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rac protein signal transduction

vesicle-mediated transport [inference]

endocytosis

actin filament-based process [inference]

actin cytoskeleton organization

postsynaptic actin cytoskeleton organization

actin filament-based movement

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

postsynaptic actin cytoskeleton organization

postsynaptic cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

lamellipodium morphogenesis

plasma membrane bounded cell projection organization [inference]

lamellipodium organization [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

lamellipodium morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

megakaryocyte development

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rac protein signal transduction

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

regulation of lamellipodium organization [inference]

regulation of lamellipodium assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium assembly

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of cell projection organization [inference]

positive regulation of plasma membrane bounded cell projection assembly [inference]

positive regulation of lamellipodium assembly

positive regulation of lamellipodium organization [inference]

positive regulation of lamellipodium assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin nucleation [inference]

positive regulation of Arp2/3 complex-mediated actin nucleation

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
lamellipodium	IBA IDA	17101133
cell-cell junction	IEA
SCAR complex	IBA IDA IMP	17101133 18560548 21107423 26428302
protein-containing complex	IDA	25097019
actin cytoskeleton	TAS	10970852

GO Hierarchy

cellular component

protein-containing complex

SCAR complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane region [inference]

basolateral plasma membrane

cell junction [inference]

synapse

anchoring junction [inference]

cell-cell junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein kinase A binding	IPI	25097019
SH3 domain binding	IPI	19798448
actin binding	IEA
cadherin binding	HDA	25468996
protein kinase A regulatory subunit binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

protein domain specific binding [inference]

SH3 domain binding

cell adhesion molecule binding [inference]

cadherin binding

protein kinase A binding

protein kinase A regulatory subunit binding

protein-containing complex binding [inference]

Arp2/3 complex binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **21 - 30** of 76 in total

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Species	Gene ID	Orthologous MAtrix
Cavia porcellus	100723274	CAVPO12326
Sarcophilus harrisii	100927851	SARHA02413
Otolemur garnettii	100951401	OTOGA03593
Pan paniscus	100979214	PANPA00727
Papio anubis	100999503	PAPAN19201
Saimiri boliviensis boliviensis	101045414	SAIBB02602
Takifugu rubripes	101064106	TAKRU06550
Felis catus	101082837	FELCA18155
Tursiops truncatus	101331152	TURTR04592
Octodon degus	101562266	OCTDE21430

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