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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

Summary

Gene Symbol

PFKFB3

Organism

Mustela putorius furo (domestic ferret)

External Links

NCBI Gene: 101684713
KEGG Gene ID: mpuf:101684713
PubChem: 101684713

Annotation

Keyword

Kinase
Multifunctional enzyme
Nucleotide-binding
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A8U0SY15
A0A8U0MWZ8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
fructose metabolic process	IEA	22301074
fructose 2,6-bisphosphate metabolic process	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

carbohydrate derivative metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

organophosphate metabolic process [inference]

fructose 2,6-bisphosphate metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytosol	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying **all 3** entries
GO Term	Evidence Code	PMID
6-phosphofructo-2-kinase activity	IEA	22301074 30032202
fructose-2,6-bisphosphate 2-phosphatase activity	IEA	30032202
ATP binding	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

carbohydrate kinase activity [inference]

phosphofructokinase activity [inference]

6-phosphofructo-2-kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

phosphofructokinase activity [inference]

6-phosphofructo-2-kinase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

fructose-2,6-bisphosphate 2-phosphatase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

6-phosphofructo-2-kinase/fructose-2

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 7** entries
Gene Ontology
6-phosphofructo-2-kinase activity
ATP binding
carbohydrate phosphorylation
catalytic activity
fructose 2,6-bisphosphate metabolic process
fructose metabolic process
nucleotide binding

Displaying **all 6** entries
InterPro
6-phosphofructo-2-kinase
Fructose-2,6-bisphosphatase
Histidine phosphatase superfamily, clade-1
Histidine phosphatase superfamily
P-loop containing nucleoside triphosphate hydrolase
Phosphoglycerate/bisphosphoglycerate mutase, active site

KEGG BRITE Database

Orthology

K01103

Name

6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 3 [EC:2.7.1.105 3.1.3.46]

References

9202288

Ortholog

Displaying entries **21 - 30** of **113** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Cavia porcellus	100726768			CAVPO09141
Cricetulus griseus	100762756			CRIGR00017
Sarcophilus harrisii	100922064			SARHA18808
Otolemur garnettii	100964227			OTOGA14612
Papio anubis	101006214			PAPAN03913
Takifugu rubripes	101065089			TAKRU18750
Felis catus	101100062	9685_0:002358		FELCA15834
Oryzias latipes	101173108			ORYLA10863
Tursiops truncatus	101325875			TURTR01014
Odobenus rosmarus divergens	101372907	9708_0:003939

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024