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MIRAGE

sprouty-related EVH1 domain containing 3

Summary

Gene Symbol

Spred3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

101809

PubChem

101809

Alliance of Genome Resources

MGI:2142186

Annotation

Keyword

Cell membrane
Methylation
Palmitate
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6P6N5
A0A0R4J0K0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
negative regulation of epithelial to mesenchymal transition	IDA	25576668
negative regulation of transforming growth factor beta receptor signaling pathway	IDA	25576668
negative regulation of MAPK cascade	IMP	12646235
negative regulation of ERK1 and ERK2 cascade	IDA	29501879
negative regulation of ERK1 and ERK2 cascade	IBA

GO Hierarchy

biological process

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of epithelial cell differentiation [inference]

negative regulation of lens fiber cell differentiation

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of epithelial cell differentiation [inference]

negative regulation of lens fiber cell differentiation

negative regulation of multicellular organismal process [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

negative regulation of epithelial to mesenchymal transition

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of lens fiber cell differentiation

regulation of lens fiber cell differentiation [inference]

negative regulation of lens fiber cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of epithelial cell differentiation [inference]

negative regulation of lens fiber cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of epithelial cell differentiation [inference]

negative regulation of lens fiber cell differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of lens fiber cell differentiation

regulation of lens fiber cell differentiation [inference]

negative regulation of lens fiber cell differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

negative regulation of epithelial to mesenchymal transition

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of lens fiber cell differentiation

regulation of lens fiber cell differentiation [inference]

negative regulation of lens fiber cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of epithelial cell differentiation [inference]

negative regulation of lens fiber cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of epithelial cell differentiation [inference]

negative regulation of lens fiber cell differentiation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of lens fiber cell differentiation

regulation of lens fiber cell differentiation [inference]

negative regulation of lens fiber cell differentiation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
plasma membrane	IDA	12646235
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
stem cell factor receptor binding	IDA	12646235
protein kinase binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

stem cell factor receptor binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sprouty

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
negative regulation of MAPK cascade
protein kinase binding

Displaying **all 5** entries
InterPro
PH-like domain superfamily
SPRE, EVH1 domain
Sprouty
WH1/EVH1 domain
c-Kit-binding domain

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025