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proteasome activator subunit 3

Summary

Gene Symbol

PSME3

Organism

Homo sapiens (human)

External Links

NCBI Gene

10197

PubChem

10197

Alliance of Genome Resources

HGNC:9570

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Apoptosis
Cell cycle
Cytoplasm
Direct protein sequencing
Host-virus interaction
Nucleus
Phosphoprotein
Proteasome
Proteomics identification
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
V9HWJ8	Activator of multicatalytic protease subunit 3 Proteasome activator 28 subunit gamma
P61289	11S regulator complex subunit gamma Activator of multicatalytic protease subunit 3 Ki nuclear autoantigen Proteasome activator 28 subunit gamma
B3KQ25
Q6MZZ1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
apoptotic process	IEA
regulation of proteasomal protein catabolic process	IDA	18309296
regulation of proteasomal protein catabolic process	IBA
regulation of G1/S transition of mitotic cell cycle	IBA
negative regulation of extrinsic apoptotic signaling pathway	IDA	18309296

GO Hierarchy

biological process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle process [inference]

regulation of cell cycle phase transition [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle G1/S phase transition [inference]

regulation of G1/S transition of mitotic cell cycle

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
proteasome complex	TAS	8811196
nucleus	HDA	21630459
nucleoplasm	IDA
nucleoplasm	IBA
cytoplasm	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

proteasome activator complex

intracellular protein-containing complex [inference]

proteasome complex

catalytic complex [inference]

peptidase complex [inference]

endopeptidase complex [inference]

proteasome complex

cellular anatomical entity [inference]

microtubule organizing center [inference]

ciliary basal body

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
p53 binding	IDA	18309296
protein binding	IPI	12970408 16189514 16439211 16713569 18309296 20580715 21516116 22190034 24722188 25416956 26871637 27107012 29934401 32296183 32703419 32814053 33961781 35271311
identical protein binding	IPI	16169070 16189514 25416956 27107012 32296183
endopeptidase activator activity	IDA	18309296
endopeptidase activator activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity

peptidase regulator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity

endopeptidase regulator activity [inference]

endopeptidase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

peptidase activator activity [inference]

endopeptidase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

proteasome activator

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
endopeptidase activator activity
regulation of G1/S transition of mitotic cell cycle
regulation of proteasomal protein catabolic process

Displaying **all 6** entries
InterPro
Proteasome activator PA28, C-terminal domain superfamily
Proteasome activator PA28, C-terminal domain
Proteasome activator PA28, N-terminal domain superfamily
Proteasome activator PA28, N-terminal domain
Proteasome activator PA28
Proteasome activator superfamily

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10197	Xenbase:XB-GENE-981879
Mus musculus	19192	Xenbase:XB-GENE-981879	MOUSE04455
Rattus norvegicus	25634		RATNO03089
Danio rerio	30649		DANRE46019
Rattus norvegicus	287716		RATNO03089
Sus scrofa	397625		PIGXX02229
Canis lupus familiaris	480512		CANLF18677
Macaca mulatta	711900		MACMU16151
Pan troglodytes	740582		PANTR13827
Ornithorhynchus anatinus	100093159		ORNAN03165