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growth differentiation factor 11

Summary

Gene Symbol

GDF11

Organism

Homo sapiens (human)

External Links

NCBI Gene

10220

PubChem

10220

Alliance of Genome Resources

HGNC:4216

Annotation

Keyword

3D-structure
Cleavage on pair of basic residues
Cytokine
Disease variant
Disulfide bond
Glycoprotein
Growth factor
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O95390	Bone morphogenetic protein 11

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
skeletal system development	TAS	10391213
metanephros development	IEA
ureteric bud development	IEA
nervous system development	TAS	10075854
mesoderm development	TAS	10075854

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

activin receptor signaling pathway

cell population proliferation

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

amacrine cell differentiation

cell maturation [inference]

epithelial cell maturation [inference]

columnar/cuboidal epithelial cell maturation [inference]

glandular epithelial cell maturation [inference]

type B pancreatic cell maturation

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification [inference]

spinal cord anterior/posterior patterning

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

camera-type eye morphogenesis

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

epithelial cell maturation [inference]

columnar/cuboidal epithelial cell maturation [inference]

glandular epithelial cell maturation [inference]

type B pancreatic cell maturation

anatomical structure development [inference]

tissue development [inference]

mesoderm development

epithelium development [inference]

kidney epithelium development [inference]

mesonephric epithelium development [inference]

mesonephric tubule development [inference]

ureteric bud development

tube development [inference]

mesonephric tubule development [inference]

ureteric bud development

animal organ development [inference]

kidney development [inference]

metanephros development

system development [inference]

roof of mouth development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

amacrine cell differentiation

cell maturation [inference]

epithelial cell maturation [inference]

columnar/cuboidal epithelial cell maturation [inference]

glandular epithelial cell maturation [inference]

type B pancreatic cell maturation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation [inference]

negative regulation of amacrine cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation [inference]

negative regulation of amacrine cell differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation [inference]

negative regulation of amacrine cell differentiation

regulation of neuron differentiation [inference]

negative regulation of neuron differentiation [inference]

negative regulation of amacrine cell differentiation

regulation of amacrine cell differentiation [inference]

negative regulation of amacrine cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation [inference]

negative regulation of amacrine cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

activin receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation [inference]

negative regulation of amacrine cell differentiation

regulation of neuron differentiation [inference]

negative regulation of neuron differentiation [inference]

negative regulation of amacrine cell differentiation

regulation of amacrine cell differentiation [inference]

negative regulation of amacrine cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell differentiation [inference]

negative regulation of neuron differentiation [inference]

negative regulation of amacrine cell differentiation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular space	IBA
nucleoplasm
protein-containing complex	IDA	24019467
intracellular membrane-bounded organelle

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytokine activity	IBA
protein binding	IPI	18596030 21054789 28257634 33961781
growth factor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Nodal

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cytokine activity
growth factor activity

Displaying **all 5** entries
InterPro
Cystine-knot cytokine
TGF-beta, propeptide
Transforming growth factor beta, conserved site
Transforming growth factor-beta, C-terminal
Transforming growth factor-beta-related

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070418	vertebral hypersegmentation and orofacial anomalies	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 61 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	2660	FB:FBgn0026199
Xenopus tropicalis	10220	Xenbase:XB-GENE-487193
Mus musculus	14561	Xenbase:XB-GENE-487193	MOUSE01634
Drosophila melanogaster	17700	FB:FBgn0026199
Drosophila melanogaster	29152	FB:FBgn0026199
Rattus norvegicus	29454	Xenbase:XB-GENE-487193	RATNO39062
Danio rerio	175237	ZFIN:ZDB-GENE-040427-2
Sus scrofa	397254		PIGXX25557
Danio rerio	406247		DANRE01708
Pan troglodytes	451970		PANTR05635

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements