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interleukin 6

Summary

Gene Symbol

Organism

Bubalus bubalis (water buffalo)

External Links

NCBI Gene: 102415101
PubChem: 102415101

Annotation

Keyword

Acute phase
Cytokine
Disulfide bond
Glycoprotein
Growth factor
Phosphoprotein
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6V919
Q2MH02

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
acute-phase response
immune response	IEA	22301074 30032202
positive regulation of cell population proliferation	IEA	30032202
vascular endothelial growth factor production
response to activity

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

vascular endothelial growth factor production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

vascular endothelial growth factor production

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

vascular endothelial growth factor production

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

vascular endothelial growth factor production

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

vascular endothelial growth factor production

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

interleukin-6-mediated signaling pathway

cell population proliferation [inference]

epithelial cell proliferation [inference]

epithelial cell proliferation involved in liver morphogenesis [inference]

hepatocyte proliferation

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

vascular endothelial growth factor production

cellular developmental process [inference]

cell fate commitment [inference]

T cell lineage commitment [inference]

alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

multicellular organismal process [inference]

cytokine production [inference]

vascular endothelial growth factor production

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration [inference]

liver regeneration

animal organ development [inference]

animal organ regeneration [inference]

liver regeneration

gland development [inference]

liver development [inference]

liver regeneration

cellular developmental process [inference]

cell fate commitment [inference]

T cell lineage commitment [inference]

alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [inference]

CD4-positive, alpha-beta T cell lineage commitment [inference]

T-helper cell lineage commitment [inference]

T-helper 17 cell lineage commitment

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response [inference]

acute-phase response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT

positive regulation of receptor signaling pathway via JAK-STAT

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of protein secretion [inference]

regulation of insulin secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of insulin secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of insulin secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of multicellular organismal process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT

positive regulation of receptor signaling pathway via JAK-STAT

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

interleukin-6-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT

positive regulation of receptor signaling pathway via JAK-STAT

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT [inference]

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via STAT

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT

positive regulation of receptor signaling pathway via JAK-STAT

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of receptor signaling pathway via STAT

positive regulation of receptor signaling pathway via JAK-STAT

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of protein secretion [inference]

regulation of insulin secretion

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

regulation of peptide hormone secretion [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	IEA	22301074 30032202
extracellular space	IEA	22301074 30032202
interleukin-6 receptor complex

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

interleukin-6 receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

interleukin-6 receptor complex

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytokine activity	IEA	22301074 30032202
interleukin-6 receptor binding	IEA	22301074
growth factor activity	IEA	30032202

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

interleukin-6 receptor binding

receptor ligand activity [inference]

growth factor receptor binding [inference]

interleukin-6 receptor binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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