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Guidelines

MIRAGE

receptor activity modifying protein 2

Summary

Gene Symbol

RAMP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

10266

PubChem

10266

Alliance of Genome Resources

HGNC:9844

Annotation

Keyword

3D-structure
Alternative splicing
Disulfide bond
Glycoprotein
Receptor
Reference proteome
Signal
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
O60895	Calcitonin-receptor-like receptor activity-modifying protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
angiogenesis	IDA	20596610
angiogenesis	IBA
vasculogenesis	IMP	16964401
sprouting angiogenesis	ISS
calcium ion transport	IDA	10882736

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

calcitonin family receptor signaling pathway [inference]

amylin receptor signaling pathway [inference]

amylin receptor 2 signaling pathway

adrenomedullin receptor signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

cell development [inference]

muscle cell development [inference]

vascular associated smooth muscle cell development

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

intracellular protein transport

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

adherens junction assembly

tight junction assembly [inference]

bicellular tight junction assembly

extracellular matrix assembly [inference]

basement membrane assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

adherens junction assembly

tight junction assembly [inference]

bicellular tight junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

adherens junction assembly

tight junction assembly [inference]

bicellular tight junction assembly

adherens junction organization [inference]

adherens junction assembly

tight junction organization [inference]

tight junction assembly [inference]

bicellular tight junction assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization [inference]

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization [inference]

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

regulation of vascular permeability [inference]

negative regulation of vascular permeability

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

sprouting angiogenesis

anatomical structure development [inference]

cell development [inference]

muscle cell development [inference]

vascular associated smooth muscle cell development

animal organ development [inference]

heart development

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

cell development [inference]

muscle cell development [inference]

vascular associated smooth muscle cell development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to vascular endothelial growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus

cellular response to growth factor stimulus [inference]

cellular response to vascular endothelial growth factor stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

intracellular protein transport

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

calcium ion transport

protein transport

intracellular protein transport

nitrogen compound transport [inference]

protein transport

intracellular protein transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

establishment of protein localization [inference]

protein transport

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

intracellular protein transport

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

regulation of vasculogenesis [inference]

positive regulation of vasculogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

calcitonin family receptor signaling pathway [inference]

amylin receptor signaling pathway [inference]

amylin receptor 2 signaling pathway

adrenomedullin receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of epithelial cell apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of endothelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

regulation of vasculogenesis [inference]

positive regulation of vasculogenesis

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell differentiation [inference]

positive regulation of vasculogenesis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of biological quality [inference]

regulation of blood pressure

regulation of vascular permeability [inference]

negative regulation of vascular permeability

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GO Term	Evidence Code	PMID
cytoplasm	IDA	10882736
lysosome	TAS	10882736
plasma membrane	TAS
plasma membrane	IDA	9620797
clathrin-coated pit	TAS	10882736

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

plasma membrane signaling receptor complex [inference]

G protein-coupled receptor complex [inference]

G protein-coupled receptor dimeric complex [inference]

adrenomedullin receptor complex

calcitonin family receptor complex [inference]

adrenomedullin receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

G protein-coupled receptor complex [inference]

G protein-coupled receptor dimeric complex [inference]

adrenomedullin receptor complex

calcitonin family receptor complex [inference]

adrenomedullin receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

clathrin-coated pit

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

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GO Term	Evidence Code	PMID
adrenomedullin receptor activity	IPI	20074556 22102369 9620797
protein binding	IPI	20596610 22102369 30115739 32296183 9620797
coreceptor activity	ISS
coreceptor activity	IDA	17916776 35324283
coreceptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

peptide hormone binding [inference]

calcitonin family binding [inference]

adrenomedullin binding

hormone binding [inference]

peptide hormone binding [inference]

calcitonin family binding [inference]

adrenomedullin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

calcitonin family receptor activity [inference]

adrenomedullin receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

calcitonin family receptor activity [inference]

adrenomedullin receptor activity

coreceptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Receptor activity-modifying protein 2

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
angiogenesis
calcium ion transport
cellular response to hormone stimulus
receptor internalization
regulation of G protein-coupled receptor signaling pathway

Displaying **all 2** entries
InterPro
RAMP domain superfamily
Receptor activity modifying protein

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 34 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	10266	ZFIN:ZDB-GENE-080204-79
Danio rerio	54409	ZFIN:ZDB-GENE-080204-79
Danio rerio	58966	ZFIN:ZDB-GENE-080204-79
Sus scrofa	397155		PIGXX02237
Pan troglodytes	454698		PANTR13841
Bos taurus	504230		BOVIN13406
Macaca mulatta	707718		MACMU16090
Callithrix jacchus	100391576		CALJA34885
Pongo abelii	100448738		PONAB12571
Equus caballus	100630685		HORSE04996

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Last updated: December 8, 2025