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katanin regulatory subunit B1

Summary

Gene Symbol

KATNB1

Organism

Homo sapiens (human)

External Links

NCBI Gene

10300

PubChem

10300

Alliance of Genome Resources

HGNC:6217

Annotation

Keyword

Cytoskeleton
Disease variant
Lissencephaly
Microtubule
Mitosis
Phosphoprotein
Reference proteome
Repeat
WD repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BVA0	p80 katanin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
positive regulation of neuron projection development	IEA
cytoplasmic microtubule organization	NAS	28436967
microtubule depolymerization	IBA
protein targeting	NAS	10751153
cell division	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule polymerization or depolymerization [inference]

microtubule depolymerization

microtubule-based movement [inference]

chromosome movement towards spindle pole [inference]

mitotic chromosome movement towards spindle pole

cell cycle process [inference]

chromosome movement towards spindle pole [inference]

mitotic chromosome movement towards spindle pole

mitotic cell cycle process [inference]

mitotic chromosome movement towards spindle pole

cell division

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein targeting

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

microtubule polymerization or depolymerization [inference]

microtubule depolymerization

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

microtubule depolymerization

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein depolymerization [inference]

microtubule depolymerization

supramolecular fiber organization [inference]

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein targeting

establishment of localization [inference]

establishment of protein localization [inference]

protein targeting

organelle localization [inference]

chromosome localization [inference]

chromosome movement towards spindle pole [inference]

mitotic chromosome movement towards spindle pole

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein targeting

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule depolymerization

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule depolymerization

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of microtubule depolymerization [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule depolymerization

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of cytoskeleton organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule depolymerization

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule depolymerization

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of microtubule depolymerization [inference]

regulation of protein-containing complex disassembly [inference]

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

regulation of protein depolymerization [inference]

regulation of microtubule depolymerization [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule depolymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of protein-containing complex disassembly [inference]

positive regulation of protein depolymerization [inference]

positive regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

regulation of supramolecular fiber organization [inference]

regulation of microtubule depolymerization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule depolymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule depolymerization

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
microtubule	IDA	26929214
membrane	HDA	19946888
spindle	IDA	26929214
katanin complex	IBA IDA IPI ISS TAS	10751153 26929214 9568719
neuronal cell body	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

katanin complex

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

cytosol

membrane

plasma membrane

site of polarized growth [inference]

growth cone

midbody

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

spindle

cytoskeleton [inference]

microtubule cytoskeleton

cell body [inference]

neuronal cell body

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	24486153 26496610 26929214 28514442 32814053 33961781
protein heterodimerization activity	IPI	10751153
dynein complex binding	IEA
ATPase regulator activity	IDA	10751153
microtubule binding	NAS	10751153

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

protein dimerization activity [inference]

protein heterodimerization activity

protein-containing complex binding [inference]

dynein complex binding

molecular function regulator activity [inference]

ATPase regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

katanin p80 WD40 repeat-containing subunit B1

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism

Displaying **all 3** entries
Gene Ontology
microtubule binding
microtubule depolymerization
microtubule severing

Displaying **all 7** entries
InterPro
G-protein beta WD-40 repeat
Katanin p80 WD40 repeat-containing subunit B1
Katanin p80 subunit, C-terminal
WD40 repeat, conserved site
WD40 repeat
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060250	idiopathic scoliosis	Alliance of Genome Resources
DOID:0112236	lissencephaly 6	Alliance of Genome Resources
DOID:10907	microcephaly	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **102** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	32581		FB:FBgn0040207
Mus musculus	74187		MGI:1921437	MOUSE59605
Caenorhabditis elegans	173271		WB:WBGene00009825
Rattus norvegicus	291852		RGD:1311256	RATNO14398
Xenopus laevis	379889		Xenbase:XB-GENE-17335261
Xenopus laevis	398032		Xenbase:XB-GENE-998277
Danio rerio	406291		ZFIN:ZDB-GENE-040426-1954
Xenopus tropicalis	407924		Xenbase:XB-GENE-998271
Pan troglodytes	467986	9598_0:00431f		PANTR12471
Bos taurus	508813			BOVIN10526

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements