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ectonucleotide pyrophosphatase/phosphodiesterase 3

Summary

Gene Symbol

ENPP3

Organism

Lipotes vexillifer (Yangtze River dolphin)

External Links

NCBI Gene: 103081773
KEGG Gene ID: lve:103081773
PubChem: 103081773

Annotation

Keyword

Disulfide bond
Metal-binding
Reference proteome
Secreted
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A340XC43	Phosphodiesterase I beta Phosphodiesterase I/nucleotide pyrophosphatase 3
A0A340X5K2	Phosphodiesterase I beta Phosphodiesterase I/nucleotide pyrophosphatase 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
nucleoside triphosphate catabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organic substance metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleic acid binding	IEA	22301074
metal ion binding	IEA	22301074
nucleoside triphosphate diphosphatase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

nucleoside triphosphate diphosphatase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Cetacea

Group Name

ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Functional Category

F: Nucleotide transport and metabolism
J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
hydrolase activity
metal ion binding
nucleoside triphosphate catabolic process
nucleoside triphosphate diphosphatase activity

Displaying **all 8** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
DNA/RNA non-specific endonuclease superfamily
DNA/RNA non-specific endonuclease
Extracellular Endonuclease, subunit A
His-Me finger superfamily
Somatomedin B domain
Somatomedin B-like domain superfamily
Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

KEGG BRITE Database

Orthology

K01513

Name

ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9]

References

Rhea

RHEA:23996

H₂O + a ribonucleoside 5'-triphosphate

H⁺ + diphosphate + a ribonucleoside 5'-phosphate

Enzyme

3.6.1.9

PMID

12218018

RHEA:29391

H₂O + GTP

H⁺ + diphosphate + GMP

Enzyme

PMID

12218018

RHEA:28334

H₂O + dATP

H⁺ + diphosphate + dAMP

Enzyme

3.6.1.9

PMID

RHEA:28610

H₂O + XTP

H⁺ + diphosphate + XMP

Enzyme

PMID

RHEA:28362

H₂O + dGTP

H⁺ + diphosphate + dGMP

Enzyme

3.6.1.9

PMID

RHEA:29399

H₂O + ITP

H⁺ + diphosphate + IMP

Enzyme

PMID

RHEA:27762

H₂O + CTP

H⁺ + diphosphate + CMP

Enzyme

PMID

RHEA:29395

H₂O + UTP

H⁺ + diphosphate + UMP

Enzyme

PMID

RHEA:28534

H₂O + dTTP

H⁺ + diphosphate + dTMP

Enzyme

3.6.1.9

PMID

RHEA:14245

H₂O + ATP

H⁺ + diphosphate + AMP

Enzyme

PMID

12218018

RHEA:44644

H₂O + a 2'-deoxyribonucleoside 5'-triphosphate

H⁺ + diphosphate + a 2'-deoxyribonucleoside 5'-phosphate

Enzyme

3.6.1.9

PMID

12218018

RHEA:28342

H₂O + dITP

H⁺ + diphosphate + dIMP

Enzyme

PMID

RHEA:22636

H₂O + dCTP

H⁺ + diphosphate + dCMP

Enzyme

PMID

RHEA:10248

H₂O + dUTP

H⁺ + dUMP + diphosphate

Enzyme

PMID

Ortholog

Displaying entries **1 - 10** of 12 in total

1

2

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Orcinus orca	101286661	9733_0:002f6d
Tursiops truncatus	101338854	9739_0:002e8b
Physeter catodon	102991712	9755_0:001d50
Balaenoptera acutorostrata	103007617	9767_0:003624
Delphinapterus leucas	111165754	9749_0:003eba
Neophocaena asiaeorientalis asiaeorientalis	112409136	1706337_0:002bbf
Lagenorhynchus obliquidens	113609194	90247_0:0004ba
Monodon monoceros	114896335	40151_0:001770
Globicephala melas	115851446	9731_1:00083f
Phocoena sinus	116763516	42100_0:003299

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Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements