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ectonucleotide pyrophosphatase/phosphodiesterase 3

Summary

Gene Symbol

ENPP3

Organism

Carlito syrichta (Philippine tarsier)

External Links

NCBI Gene: 103274446
KEGG Gene ID: csyr:103274446
PubChem: 103274446

Annotation

Keyword

Disulfide bond
Metal-binding
Reference proteome
Secreted
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A1U7UW21	Phosphodiesterase I beta Phosphodiesterase I/nucleotide pyrophosphatase 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
nucleoside triphosphate catabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organic substance metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside triphosphate catabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
metal ion binding	IEA	22301074
nucleic acid binding	IEA	22301074
nucleoside triphosphate diphosphatase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

nucleoside triphosphate diphosphatase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K01513

Name

ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9]

References

Rhea

H₂O + UTP

H⁺ + diphosphate + UMP

Enzyme

PMID

H₂O + dUTP

H⁺ + dUMP + diphosphate

Enzyme

PMID

H₂O + dGTP

H⁺ + diphosphate + dGMP

Enzyme

3.6.1.9

PMID

H₂O + CTP

H⁺ + diphosphate + CMP

Enzyme

PMID

H₂O + dCTP

H⁺ + diphosphate + dCMP

Enzyme

PMID

H₂O + XTP

H⁺ + diphosphate + XMP

Enzyme

PMID

H₂O + dTTP

H⁺ + diphosphate + dTMP

Enzyme

3.6.1.9

PMID

H₂O + a 2'-deoxyribonucleoside 5'-triphosphate

H⁺ + diphosphate + a 2'-deoxyribonucleoside 5'-phosphate

Enzyme

3.6.1.9

PMID

12218018

H₂O + dITP

H⁺ + diphosphate + dIMP

Enzyme

PMID

H₂O + GTP

H⁺ + diphosphate + GMP

Enzyme

PMID

12218018

H₂O + dATP

H⁺ + diphosphate + dAMP

Enzyme

3.6.1.9

PMID

H₂O + ITP

H⁺ + diphosphate + IMP

Enzyme

PMID

H₂O + ATP

H⁺ + diphosphate + AMP

Enzyme

PMID

12218018

H₂O + a ribonucleoside 5'-triphosphate

H⁺ + diphosphate + a ribonucleoside 5'-phosphate

Enzyme

3.6.1.9

PMID

12218018

Ortholog

Displaying entries **31 - 40** of 61 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Oryctolagus cuniculus	100353278		RABIT02836
Dipodomys ordii	105993494		DIPOR11165
Mus musculus	209558		MOUSE02169
Rattus norvegicus	54410		RATNO19169
Octodon degus	101580854		OCTDE07788
Heterocephalus glaber	101705137		HETGA04765
Melopsittacus undulatus	101867841		MELUD05413
Monodelphis domestica	100031034		MONDO12680
Pelodiscus sinensis	102447842		PELSI04208
Anolis carolinensis	100562470		ANOCA01488

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024