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tryptophanyl tRNA synthetase 2, mitochondrial

Summary

Gene Symbol

WARS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

10352

PubChem

10352

Alliance of Genome Resources

HGNC:12730

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Aminoacyl-tRNA synthetase
Disease variant
Dystonia
Mitochondrion
Parkinsonism
Primary mitochondrial disease
Protein biosynthesis
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UGM6	(Mt)TrpRS Tryptophanyl-tRNA synthetase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
positive regulation of angiogenesis	IEA
mitochondrial tryptophanyl-tRNA aminoacylation	IBA
tRNA aminoacylation for protein translation	TAS
vasculogenesis	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

tryptophanyl-tRNA aminoacylation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

tRNA aminoacylation for mitochondrial protein translation [inference]

mitochondrial tryptophanyl-tRNA aminoacylation

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	IDA
nucleoplasm	IDA
mitochondrion	HTP IBA IDA	10828066 34800366
mitochondrial matrix	IBA IDA TAS	28236339

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 2** entries
GO Term	Evidence Code	PMID
tryptophan-tRNA ligase activity	IBA IDA TAS	10828066
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-oxygen bonds [inference]

aminoacyl-tRNA ligase activity [inference]

tryptophan-tRNA ligase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

aminoacyl-tRNA ligase activity [inference]

tryptophan-tRNA ligase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Tryptophan--trna ligase

Functional Category

J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
ligase activity
mitochondrial tryptophanyl-tRNA aminoacylation
nucleotide binding
tRNA aminoacylation for protein translation
tryptophan-tRNA ligase activity
tryptophanyl-tRNA aminoacylation

Displaying **all 4** entries
InterPro
Aminoacyl-tRNA synthetase, class I, conserved site
Aminoacyl-tRNA synthetase, class Ic
Rossmann-like alpha/beta/alpha sandwich fold
Tryptophan-tRNA ligase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:700	mitochondrial metabolism disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	39989		FB:FBgn0036763
Mus musculus	70560		MGI:1917810	MOUSE37804
Caenorhabditis elegans	175719		WB:WBGene00006946
Pan troglodytes	457162	9598_0:00042b		PANTR21880
Canis lupus familiaris	483145			CANLF05307
Danio rerio	503745		ZFIN:ZDB-GENE-050306-26	DANRE43938
Bos taurus	532903			BOVIN26141
Rattus norvegicus	690654		RGD:1593417	RATNO23399
Macaca mulatta	712332			MACMU21896
Saccharomyces cerevisiae S288C	851861		SGD:S000002676

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements