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Guidelines

MIRAGE

alkaline ceramidase 3

Summary

Gene Symbol

ACER3

Organism

Ursus maritimus (polar bear)

External Links

NCBI Gene: 103678067
KEGG Gene ID: umr:103678067
PubChem: 103678067

Annotation

Keyword

Calcium
Hydrolase
Metal-binding
Reference proteome
Sphingolipid metabolism
Transmembrane helix
Zinc

Proteins

Displaying **all 6** entries
UniProt	Protein Name
A0A8M1FWH2
A0A8M1G3E4
A0A8M1G3E9
A0A8M1FTX8
A0A8M1FXB5
A0A8M1FWG8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
ceramide metabolic process	IEA	22301074 30032202
phytosphingosine biosynthetic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

phytosphingosine biosynthetic process

amide metabolic process [inference]

ceramide metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

sphingoid metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

phytosphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

phytosphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

sphingoid metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

sphingoid metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

sphingoid metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

sphingoid metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

phytosphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

sphingoid metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alkaline

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ceramide biosynthetic process
ceramide catabolic process
ceramide metabolic process
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
hydrolase activity
phytoceramidase activity
sphingolipid metabolic process

Displaying 1 entry
InterPro
Alkaline ceramidase

KEGG BRITE Database

Orthology

K04711

Name

dihydroceramidase [EC:3.5.1.-]

References

11356846

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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026