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choline/ethanolamine phosphotransferase 1

Summary

Gene Symbol

CEPT1

Organism

Homo sapiens (human)

External Links

NCBI Gene

10390

HGNC

24289

KEGG Gene ID

hsa:10390

PubChem

10390

Alliance of Genome Resources

HGNC:24289

Annotation

Keyword

3D-structure
Endoplasmic reticulum
Glycoprotein
Magnesium
Manganese
Metal-binding
Nucleus
Phospholipid biosynthesis
Phosphoprotein
Proteomics identification
Reference proteome
Transferase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9Y6K0	1-alkenyl-2-acylglycerol choline phosphotransferase
A0A8V8TRF3	1-alkenyl-2-acylglycerol choline phosphotransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
lipid metabolic process		10191259
phosphatidylethanolamine biosynthetic process	IBA IEA
CDP-choline pathway	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

primary metabolic process [inference]

lipid metabolic process

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organic substance metabolic process [inference]

lipid metabolic process

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phosphatidylcholine biosynthetic process [inference]

CDP-choline pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IBA TAS
membrane		10191259
nuclear membrane	IEA
Golgi apparatus	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
diacylglycerol cholinephosphotransferase activity	IBA
ethanolaminephosphotransferase activity	IBA
metal ion binding	IEA
protein binding	IPI	32296183
1-alkenyl-2-acylglycerol choline phosphotransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

phosphotransferase activity, for other substituted phosphate groups [inference]

CDP-alcohol phosphatidyltransferase activity [inference]

1-alkenyl-2-acylglycerol choline phosphotransferase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K13644

Name

choline/ethanolamine phosphotransferase [EC:2.7.8.1 2.7.8.2]

References

Rhea

CDP-ethanolamine + 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol

H⁺ + CMP + 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine

Enzyme

2.7.8.1

a 1,2-diacyl-sn-glycerol + CDP-ethanolamine

H⁺ + CMP + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine

Enzyme

2.7.8.1

PMID

a 1,2-diacyl-sn-glycerol + CDP-choline

H⁺ + a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP

Enzyme

2.7.8.2

PMID

a 1-O-alkyl-2-acetyl-sn-glycerol + CDP-choline

H⁺ + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CMP

Enzyme

2.7.8.2

CDP-choline + 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol

H⁺ + CMP + 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine

Enzyme

2.7.8.22

PMID

3447597

1-O-alkyl-2-acyl-sn-glycerol + CDP-choline

H⁺ + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP

Enzyme

2.7.8.2

Disease

Disease Ontology

Displaying entries **11 - 20** of 26 in total

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DO ID	Disease Name	Source
DOID:0110751	type 1 diabetes mellitus 12	DisGeNET
DOID:0110752	type 1 diabetes mellitus 13	DisGeNET
DOID:0110753	type 1 diabetes mellitus 15	DisGeNET
DOID:0110754	type 1 diabetes mellitus 17	DisGeNET
DOID:0110755	type 1 diabetes mellitus 18	DisGeNET
DOID:0110756	type 1 diabetes mellitus 19	DisGeNET
DOID:0110757	type 1 diabetes mellitus 20	DisGeNET
DOID:0110758	type 1 diabetes mellitus 21	DisGeNET
DOID:0110759	type 1 diabetes mellitus 22	DisGeNET
DOID:0110760	type 1 diabetes mellitus 23	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002380
Gene Name: choline/ethanolamine phosphotransferase 1

Ortholog

Displaying entries **51 - 60** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Dipodomys ordii	105991945		DIPOR14964
Cricetulus griseus	100773070		CRIGR23009
Mus musculus	99712	MGI:2139793	MOUSE38828
Rattus norvegicus	310773	RGD:1359727	RATNO25232
Cavia porcellus	100736166		CAVPO01389
Monodelphis domestica	100030357		MONDO14211
Pelodiscus sinensis	102461379		PELSI15964
Anolis carolinensis	100567654		ANOCA06445
Ursus maritimus	103675028		URSMA12427
Vombatus ursinus	114039097		VOMUR23404

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Last updated: August 19, 2024