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ST3 beta-galactoside alpha-2,3-sialyltransferase 6

Summary

Gene Symbol

ST3GAL6

Aliases

ST3GALVI

Organism

Homo sapiens (human)

External Links

NCBI Gene

10402

GGDB ID

gg053

HGNC

18080

mRNA

NM_006100

map

3q12.

Protein

NP_006091

OMIM

607156

KEGG Gene ID

hsa:10402

PubChem

10402

Alliance of Genome Resources

HGNC:18080

Annotation

Keyword

Alternative splicing
Glycoprotein
Glycosyltransferase
Golgi apparatus
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9Y274	CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI ST3Gal VI Sialyltransferase 10
A0A087WXB8	CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI ST3Gal VI Sialyltransferase 10

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
oligosaccharide biosynthetic process	TAS
keratan sulfate biosynthetic process	TAS
glycolipid biosynthetic process	IBA
protein glycosylation	IBA IDA	10206952
cellular response to interleukin-6	IEP	17944600

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycolipid biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycolipid biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-6

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to interleukin-6 [inference]

cellular response to interleukin-6

cellular response to cytokine stimulus [inference]

cellular response to interleukin-6

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-6

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-6

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-6

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	NAS	10206952
extracellular exosome	HDA	19199708 23533145
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
beta-galactoside alpha-2,3-sialyltransferase activity
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IDA TAS	10206952
sialyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000064225

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg053

Gene Symbol

ST3GAL6

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
CMP-Neu5Ac	G00055MO	G00065MO	10206952

Displaying **all 3** entries
Donor	Acceptor	Product	Reference
CMP-Neu5Ac	G00055MO	G00065MO	10206952
CMP-Neu5Ac	G58896AZ	G01767JJ	10206952
CMP-Neu5Ac	G84034JH	G03067VG	10206952

Displaying entries **1 - 10** of 13 in total

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Donor	Acceptor	Reference
CMP-Neu5Ac	G37184KW	10206952
CMP-Neu5Ac	G00056MO	10206952
CMP-Neu5Ac	G72002FC	10206952
CMP-Neu5Ac	G79389NT	10206952
CMP-Neu5Ac	G65889KE	10206952
CMP-Neu5Ac	G00031MO	10206952
CMP-Neu5Ac	G00049MO	10206952
CMP-Neu5Ac	G84224TW	10206952
CMP-Neu5Ac	G91237TK	10206952
CMP-Neu5Ac	G48558GR	10206952

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	NP_997485	NM_207602
Mus musculus	NP_061254	NM_018784

KEGG BRITE Database

Orthology

K03792

Name

N-acetyllactosaminide alpha-2,3-sialyltransferase (sialyltransferase 10) [EC:2.4.3.6]

References

10206952

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R06026	2.4.3.6	G58896AZ	G01767JJ
R06037	2.4.3.6	G84034JH	G03067VG

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:10534	stomach cancer	DisGeNET
DOID:162	cancer	DisGeNET
DOID:305	carcinoma	DisGeNET
DOID:3571	liver cancer	DisGeNET
DOID:4015	sarcomatoid carcinoma	DisGeNET
DOID:5672	large intestine cancer	DisGeNET
DOID:684	hepatocellular carcinoma	DisGeNET
DOID:9256	colorectal cancer	DisGeNET
DOID:9538	multiple myeloma	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001754
Gene Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 6

Ortholog

Displaying entries **1 - 10** of 63 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Callorhinchus milii	103180110		CALMI19732
Danio rerio	554166	ZFIN:ZDB-GENE-060322-2
Xenopus laevis	398745	Xenbase:XB-GENE-947399
Xenopus laevis	108709199	Xenbase:XB-GENE-17336588
Xenopus tropicalis	402790	Xenbase:XB-GENE-947392
Chrysemys picta bellii	101932642		CHRPI32004
Meleagris gallopavo	100541741		MELGA01075
Serinus canaria	103827065		SERCA01019
Ornithorhynchus anatinus	100681144		ORNAN09338
Sarcophilus harrisii	100923762		SARHA07086

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements