GlyCosmos Portal

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell membrane
Cytoplasm
Endoplasmic reticulum
Fatty acid metabolism
Hydrolase
Membrane
Nucleus
Proteomics identification
Reference proteome

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A087X1K9	Lysophospholipase 1 Lysophospholipase I Palmitoyl-protein hydrolase
O75608	Lysophospholipase 1 Lysophospholipase I Palmitoyl-protein hydrolase
B4DP64	Lysophospholipase 1 Lysophospholipase I Palmitoyl-protein hydrolase
Q6IAQ1	Lysophospholipase 1 Lysophospholipase I Palmitoyl-protein hydrolase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
fatty acid metabolic process	IEA
fatty acid transport	IDA	32958780
protein depalmitoylation	IBA IDA IMP	19439193 27481942
negative regulation of aggrephagy	IDA	37802024
negative regulation of Golgi to plasma membrane protein transport	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

macromolecule modification [inference]

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

macromolecule deacylation [inference]

protein deacylation [inference]

protein depalmitoylation

macromolecule depalmitoylation [inference]

protein depalmitoylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoylation

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport [inference]

fatty acid transport

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

regulation of macroautophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

regulation of aggrephagy [inference]

negative regulation of aggrephagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

regulation of macroautophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

regulation of aggrephagy [inference]

negative regulation of aggrephagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of protein transport [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of vesicle-mediated transport [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of transport [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

regulation of macroautophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

regulation of aggrephagy [inference]

negative regulation of aggrephagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of aggrephagy

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane [inference]

negative regulation of Golgi to plasma membrane protein transport

regulation of vesicle-mediated transport [inference]

regulation of Golgi to plasma membrane protein transport [inference]

negative regulation of Golgi to plasma membrane protein transport

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	19439193
cytosol	IDA TAS
cytoplasm	IBA IDA	19439193
plasma membrane	IDA	19439193 32958780
nuclear membrane	IDA	19439193

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

nuclear membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
phospholipase activity	IDA	21393252
palmitoyl-(protein) hydrolase activity	IBA IDA IMP	19439193 20418879 32958780 37802024
lysophospholipase activity	IDA	19439193 21393252
protein binding	IPI	32296183
carboxylic ester hydrolase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity

phospholipase activity

lysophospholipase activity

thiolester hydrolase activity [inference]

palmitoyl-(protein) hydrolase activity

carboxylic ester hydrolase activity

lysophospholipase activity

palmitoyl hydrolase activity [inference]

palmitoyl-(protein) hydrolase activity

catalytic activity, acting on a protein [inference]

palmitoyl-(protein) hydrolase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000120992

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K06128

Name

lysophospholipase I [EC:3.1.1.5]

References

9139730

Rhea

RHEA:19233

H₂O

H⁺ + hexadecanoate

Enzyme

3.1.2.22

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 19 in total

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DO ID	Disease Name	Source
DOID:10283	prostate cancer	DisGeNET
DOID:10286	prostate carcinoma	DisGeNET
DOID:1324	lung cancer	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1793	pancreatic cancer	DisGeNET
DOID:1909	melanoma	DisGeNET
DOID:1936	atherosclerosis	DisGeNET
DOID:2348	arteriosclerotic cardiovascular disease	DisGeNET
DOID:2349	arteriosclerosis	DisGeNET
DOID:305	carcinoma	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001786
Gene Name: lysophospholipase I

Ortholog

Displaying entries **1 - 10** of 57 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	172587	WB:WBGene00010564
Drosophila melanogaster	59176	FB:FBgn0042138
Callorhinchus milii	103186721		CALMI35310
Callorhinchus milii	121848086		CALMI35310
Latimeria chalumnae	102364020		LATCH15369
Danio rerio	550279	ZFIN:ZDB-GENE-050417-87
Astyanax mexicanus	103021974		ASTMX15262
Ictalurus punctatus	108268102		ICTPU32454
Electrophorus electricus	113579301		ELEEL23568
Salmo salar	100196016		SALSA101941

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements