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cyclase associated actin cytoskeleton regulatory protein 2

Summary

Gene Symbol

CAP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

10486

PubChem

10486

Alliance of Genome Resources

HGNC:20039

Annotation

Keyword

Acetylation
Alternative splicing
Cardiomyopathy
Cell membrane
Disease variant
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P40123
Q5JPJ8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cell morphogenesis	IBA
actin filament organization	IBA
establishment or maintenance of cell polarity	TAS	7962207
signal transduction	TAS	7962207
activation of adenylate cyclase activity	TAS	7962207

GO Hierarchy

biological process

cellular process [inference]

establishment or maintenance of cell polarity

signal transduction

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

actin filament-based process [inference]

actin cytoskeleton organization [inference]

presynaptic actin cytoskeleton organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

presynaptic actin cytoskeleton organization

presynaptic cytoskeleton organization [inference]

presynaptic actin cytoskeleton organization

supramolecular fiber organization [inference]

actin filament organization

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

cyclic-nucleotide-mediated signaling [inference]

cAMP-mediated signaling

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of modification of synaptic structure [inference]

regulation of modification of postsynaptic structure [inference]

regulation of modification of postsynaptic actin cytoskeleton

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

regulation of catalytic activity [inference]

regulation of cyclase activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

regulation of lyase activity [inference]

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity [inference]

activation of adenylate cyclase activity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA
plasma membrane	IEA
postsynaptic density	IEA
glutamatergic synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

Displaying **all 4** entries
GO Term	Evidence Code	PMID
actin binding	IBA
protein binding	IPI	25416956 25910212 28514442 32296183 33961781 35271311
adenylate cyclase binding	IBA
identical protein binding	IPI	25416956 32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

enzyme binding [inference]

adenylate cyclase binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
SLC35B1-4/HUT1

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10486	Xenbase:XB-GENE-982188
Saccharomyces cerevisiae S288C	10487	SGD:S000005082
Saccharomyces cerevisiae S288C	12331	SGD:S000005082
Mus musculus	67252	Xenbase:XB-GENE-982188	MOUSE10522
Rattus norvegicus	116653		RATNO12931
Pan troglodytes	462454		PANTR37291
Canis lupus familiaris	478731		CANLF13752
Bos taurus	515190		BOVIN19174
Macaca mulatta	703445		MACMU35241
Monodelphis domestica	100025421		MONDO17252

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Annotation

OrthoDB (Group)

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Acknowledgements