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Guidelines

MIRAGE

semaphorin 3C

Summary

Gene Symbol

SEMA3C

Organism

Homo sapiens (human)

External Links

NCBI Gene

10512

PubChem

10512

Alliance of Genome Resources

HGNC:10725

Annotation

Keyword

Alternative splicing
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Neurogenesis
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q99985	Semaphorin-E

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 20 in total

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GO Term	Evidence Code	PMID
post-embryonic development	IEA
neural tube development	IEA
positive regulation of cell migration	IBA
negative chemotaxis	IBA
limb bud formation	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

cardiac endothelial to mesenchymal transition

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification [inference]

somitogenesis

segmentation [inference]

somitogenesis

post-embryonic development

tissue remodeling [inference]

blood vessel remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

cardiac chamber morphogenesis [inference]

cardiac ventricle morphogenesis [inference]

cardiac right ventricle morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

dichotomous subdivision of an epithelial terminal unit [inference]

dichotomous subdivision of terminal units involved in salivary gland branching

cardiac septum morphogenesis [inference]

outflow tract septum morphogenesis

anatomical structure formation involved in morphogenesis [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

neural tube development

muscle tissue development [inference]

striated muscle tissue development [inference]

pulmonary myocardium development

tube development [inference]

neural tube development

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

cardiac endothelial to mesenchymal transition

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

response to stimulus [inference]

immune response

response to chemical [inference]

response to xenobiotic stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [inference]

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [inference]

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular space	IBA
plasma membrane	IBA
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	33961781
semaphorin receptor binding	IBA
neuropilin binding	IBA
chemorepellent activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

chemorepellent activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

semaphorin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
chemorepellent activity
negative regulation of axon extension involved in axon guidance
neural crest cell migration
positive regulation of cell migration
semaphorin receptor binding
semaphorin-plexin signaling pathway

Displaying **all 5** entries
InterPro
PSI domain
Sema domain superfamily
Sema domain
Semaphorin
WD40/YVTN repeat-like-containing domain superfamily

Ortholog

Displaying entries **61 - 70** of **134** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Sus scrofa	100624508		PIGXX36320
Loxodonta africana	100665779		LOXAF17749
Oreochromis niloticus	100697969		ORENI24793
Cavia porcellus	100730457		CAVPO14296
Cricetulus griseus	100765927		CRIGR13282
Sarcophilus harrisii	100915955		SARHA03040
Otolemur garnettii	100962931		OTOGA17862
Pan paniscus	100984137		PANPA36543
Papio anubis	101019247		PAPAN30491
Saimiri boliviensis boliviensis	101044556		SAIBB02351

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GlyCosmos Portal v4.1.1

Last updated: February 17, 2025