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prolyl 3-hydroxylase 3

Summary

Gene Symbol

P3H3

Organism

Homo sapiens (human)

External Links

NCBI Gene

10536

PubChem

10536

Alliance of Genome Resources

HGNC:19318

Annotation

Keyword

Alternative splicing
Coiled coil
Dioxygenase
Endoplasmic reticulum
Glycoprotein
Iron
Metal-binding
Reference proteome
Repeat
Signal
TPR repeat
Vitamin C

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IVL6	Leprecan-like protein 2 Protein B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
negative regulation of cell population proliferation	IDA	19436308
peptidyl-lysine hydroxylation	ISS
collagen metabolic process	IBA
collagen biosynthetic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

biosynthetic process [inference]

collagen biosynthetic process

collagen metabolic process

collagen biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

macromolecule modification [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA
catalytic complex	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	PMID
iron ion binding	IEA
protein binding	IPI	32296183 32814053
procollagen-proline 3-dioxygenase activity	IBA
L-ascorbic acid binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

peptidyl-proline 3-dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

peptidyl-proline 3-dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

catalytic activity, acting on a protein [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

peptidyl-proline 3-dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Prolyl 3-hydroxylase 3

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
L-ascorbic acid binding
collagen metabolic process
dioxygenase activity
iron ion binding
metal ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
procollagen-proline 3-dioxygenase activity

Displaying **all 5** entries
InterPro
Oxoglutarate/iron-dependent dioxygenase
Prolyl 3-hydroxylase
Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Prolyl 4-hydroxylase, alpha subunit
Tetratricopeptide-like helical domain superfamily

Ortholog

Displaying entries **31 - 40** of 74 in total

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Species	Gene ID	Orthologous MAtrix
Chlorocebus sabaeus	103218477	CHLSB01880
Cynoglossus semilaevis	103387968	CYNSE05707
Poecilia reticulata	103477971	POERE10412
Nannospalax galili	103727504	NANGA05229
Rhinopithecus roxellana	104680134	RHIRO25400
Esox lucius	105028240	ESOLU59877
Macaca nemestrina	105484207	MACNE35553
Cercocebus atys	105583037	CERAT29962
Aotus nancymaae	105731184	AOTNA38347
Propithecus coquereli	105805047	PROCO19197

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OrthoDB (Group)

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Acknowledgements