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cytochrome P450 family 1 subfamily A member 1

Summary

Gene Symbol

CYP1A1

Organism

Mandrillus leucophaeus (drill)

External Links

NCBI Gene: 105530835
KEGG Gene ID: mleu:105530835
PubChem: 105530835

Annotation

Keyword

Heme
Lipid metabolism
Lyase
Microsome
Monooxygenase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A2K5XC72

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
hormone biosynthetic process	IEA	30032202
progesterone metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

hormone biosynthetic process

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

hormone biosynthetic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

small molecule metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular ketone metabolic process [inference]

progesterone metabolic process

olefinic compound metabolic process [inference]

progesterone metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

hormone biosynthetic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
steroid 17-alpha-monooxygenase activity	IEA	30032202
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA	22301074
iron ion binding	IEA	22301074
heme binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

steroid hydroxylase activity [inference]

steroid 17-alpha-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Cercopithecoidea

Group Name

Cytochrome P450

Functional Category

C: Energy production and conversion
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
V: Defense mechanisms

Displaying entry **31 - 31** of 31 in total

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Gene Ontology
vitamin D 24-hydroxylase activity

Displaying **all 5** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I, CYP1
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

KEGG BRITE Database

Orthology

K07408

Name

cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]

References

Rhea

an organic molecule + O₂

H₂O + H⁺ + an alcohol

Enzyme

1.14.14.1

PMID

Ortholog

Displaying entries **91 - 92** of 92 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Macaca thibetana thibetana	126960000	257877_1:001ffc
Oryctolagus cuniculus	127489545			RABIT17918

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024