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peptidylprolyl isomerase F (cyclophilin F)

Summary

Gene Symbol

Ppif

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

105675

PubChem

105675

Alliance of Genome Resources

MGI:2145814

Annotation

Keyword

Acetylation
Apoptosis
Mitochondrion
Necrosis
Reference proteome
Rotamase
S-nitrosylation
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q99KR7	Cyclophilin D Cyclophilin F Rotamase F

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 39 in total

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GO Term	Evidence Code	PMID
protein peptidyl-prolyl isomerization	ISO
response to ischemia	IMP	15800626 16103352
regulation of transcription by RNA polymerase II	IEA
protein folding	IBA
protein folding	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

protein peptidyl-prolyl isomerization

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

protein peptidyl-prolyl isomerization

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

protein peptidyl-prolyl isomerization

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

protein peptidyl-prolyl isomerization

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

protein peptidyl-prolyl isomerization

cellular process [inference]

protein folding

cell death [inference]

programmed cell death

apoptotic process

programmed necrotic cell death [inference]

necroptotic process

cellular developmental process [inference]

cell differentiation [inference]

skeletal muscle cell differentiation [inference]

skeletal muscle fiber differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

myotube differentiation [inference]

skeletal muscle fiber differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to arsenic-containing substance

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

mitochondrial membrane organization [inference]

regulation of mitochondrial membrane permeability

positive regulation of mitochondrial membrane permeability [inference]

mitochondrial outer membrane permeabilization involved in programmed cell death

regulation of mitochondrial membrane permeability involved in programmed necrotic cell death

apoptotic mitochondrial changes

membrane organization [inference]

mitochondrial membrane organization [inference]

regulation of mitochondrial membrane permeability

positive regulation of mitochondrial membrane permeability [inference]

mitochondrial outer membrane permeabilization involved in programmed cell death

regulation of mitochondrial membrane permeability involved in programmed necrotic cell death

developmental process [inference]

anatomical structure development [inference]

muscle structure development

cellular developmental process [inference]

cell differentiation [inference]

skeletal muscle cell differentiation [inference]

skeletal muscle fiber differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

myotube differentiation [inference]

skeletal muscle fiber differentiation

response to stimulus [inference]

response to stress [inference]

response to ischemia

response to oxidative stress

response to reactive oxygen species [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to chemical [inference]

response to organic substance [inference]

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

response to calcium ion [inference]

cellular response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

response to arsenic-containing substance [inference]

cellular response to arsenic-containing substance

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to arsenic-containing substance

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

response to hydrogen peroxide [inference]

cellular response to hydrogen peroxide

response to calcium ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to calcium ion

response to salt [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to arsenic-containing substance

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species [inference]

cellular response to hydrogen peroxide

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular respiration [inference]

negative regulation of oxidative phosphorylation

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

negative regulation of cellular metabolic process [inference]

negative regulation of cellular respiration [inference]

negative regulation of oxidative phosphorylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of generation of precursor metabolites and energy [inference]

regulation of cellular respiration [inference]

negative regulation of cellular respiration [inference]

negative regulation of oxidative phosphorylation

regulation of aerobic respiration [inference]

regulation of oxidative phosphorylation [inference]

negative regulation of oxidative phosphorylation

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of proton-transporting ATPase activity, rotational mechanism

regulation of oxidative phosphorylation uncoupler activity [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of oxidative phosphorylation uncoupler activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of oxidative phosphorylation uncoupler activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of proton transport [inference]

regulation of proton-transporting ATPase activity, rotational mechanism

regulation of oxidative phosphorylation uncoupler activity [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of cation transmembrane transport [inference]

negative regulation of oxidative phosphorylation uncoupler activity

regulation of monoatomic ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of oxidative phosphorylation uncoupler activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of proton transport [inference]

regulation of proton-transporting ATPase activity, rotational mechanism

regulation of oxidative phosphorylation uncoupler activity [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of cation transmembrane transport [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular respiration [inference]

negative regulation of oxidative phosphorylation

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular respiration [inference]

negative regulation of oxidative phosphorylation

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of apoptotic signaling pathway [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of release of cytochrome c from mitochondria

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of oxidative phosphorylation uncoupler activity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

negative regulation of cellular metabolic process [inference]

negative regulation of cellular respiration [inference]

negative regulation of oxidative phosphorylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of generation of precursor metabolites and energy [inference]

regulation of cellular respiration [inference]

negative regulation of cellular respiration [inference]

negative regulation of oxidative phosphorylation

regulation of aerobic respiration [inference]

regulation of oxidative phosphorylation [inference]

negative regulation of oxidative phosphorylation

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of proton-transporting ATPase activity, rotational mechanism

regulation of oxidative phosphorylation uncoupler activity [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of oxidative phosphorylation uncoupler activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of oxidative phosphorylation uncoupler activity

regulation of monoatomic cation transmembrane transport [inference]

regulation of proton transport [inference]

regulation of proton-transporting ATPase activity, rotational mechanism

regulation of oxidative phosphorylation uncoupler activity [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of cation transmembrane transport [inference]

negative regulation of oxidative phosphorylation uncoupler activity

regulation of programmed cell death [inference]

regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic signaling pathway [inference]

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of apoptotic signaling pathway [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular respiration [inference]

negative regulation of oxidative phosphorylation

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of apoptotic signaling pathway [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of release of cytochrome c from mitochondria

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of release of cytochrome c from mitochondria

regulation of mitochondrion organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of release of cytochrome c from mitochondria

regulation of release of cytochrome c from mitochondria [inference]

negative regulation of release of cytochrome c from mitochondria

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of release of cytochrome c from mitochondria

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of mitochondrial membrane potential [inference]

mitochondrial depolarization

membrane depolarization [inference]

mitochondrial depolarization

regulation of membrane permeability [inference]

regulation of mitochondrial membrane permeability

positive regulation of mitochondrial membrane permeability [inference]

mitochondrial outer membrane permeabilization involved in programmed cell death

regulation of mitochondrial membrane permeability involved in programmed necrotic cell death

positive regulation of membrane permeability [inference]

positive regulation of mitochondrial membrane permeability [inference]

mitochondrial outer membrane permeabilization involved in programmed cell death

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of proton-transporting ATPase activity, rotational mechanism

regulation of oxidative phosphorylation uncoupler activity [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of transporter activity [inference]

negative regulation of oxidative phosphorylation uncoupler activity

regulation of ATP-dependent activity [inference]

negative regulation of molecular function [inference]

negative regulation of transporter activity [inference]

negative regulation of oxidative phosphorylation uncoupler activity

negative regulation of ATP-dependent activity

Displaying entries **11 - 12** of 12 in total

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GO Term	Evidence Code	PMID
mitochondrial matrix	ISO
mitochondrial matrix	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex [inference]

mitochondrial permeability transition pore complex

mitochondrial protein-containing complex [inference]

mitochondrial permeability transition pore complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
peptidyl-prolyl cis-trans isomerase activity	ISS
peptidyl-prolyl cis-trans isomerase activity	ISO
peptidyl-prolyl cis-trans isomerase activity	TAS	18309324
peptidyl-prolyl cis-trans isomerase activity	IBA
protein binding	IPI	22726440 32814053