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carboxyl ester lipase

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

1056

KEGG Gene ID

hsa:1056

PubChem

1056

Alliance of Genome Resources

HGNC:1848

Annotation

Keyword

Hydrolase
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B4DSX9
O75612
Q86SR3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
pancreatic juice secretion	IBA IDA	1854805
intestinal cholesterol absorption	IDA	12031288
ceramide catabolic process	IBA
retinol metabolic process	IEA
lipid metabolic process		8639615

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

hormone metabolic process [inference]

retinol metabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

primary metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic substance metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

olefinic compound metabolic process [inference]

retinol metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ceramide catabolic process

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

pancreatic juice secretion

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

secretion by tissue [inference]

pancreatic juice secretion

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

body fluid secretion [inference]

pancreatic juice secretion

secretion by tissue [inference]

pancreatic juice secretion

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

intestinal cholesterol absorption

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

intestinal cholesterol absorption

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

regulation of body fluid levels [inference]

body fluid secretion [inference]

pancreatic juice secretion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region
extracellular space	HDA	16502470
cytoplasm	ISS
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
retinyl-palmitate esterase activity	IBA
sterol esterase activity	IBA NAS	12031288
protein binding	IPI	11834744
triglyceride lipase activity	IBA NAS	2265692
heparin binding		7578248

GO Hierarchy

molecular function

catalytic activity

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

carboxylic ester hydrolase activity [inference]

short-chain carboxylesterase activity [inference]

acetylesterase activity

retinyl-palmitate esterase activity

binding [inference]

protein binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

hydrolase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
hydrolase activity

Displaying **all 2** entries
InterPro
Alpha/Beta hydrolase fold
Carboxylesterase, type B

Human Protein Atlas

ENSG00000170835

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K12298

Name

bile salt-stimulated lipase [EC:3.1.1.3 3.1.1.13]

References

Disease

The Human Phenotype Ontology

Displaying entries **1 - 10** of 25 in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000077	Abnormality of the kidney
HP:0000107	Renal cyst
HP:0000112	Nephropathy
HP:0000119	Abnormality of the genitourinary system
HP:0000488	Retinopathy
HP:0000825	Hyperinsulinemic hypoglycemia
HP:0000831	Insulin-resistant diabetes mellitus
HP:0000956	Acanthosis nigricans
HP:0001511	Intrauterine growth retardation

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:552	maturity-onset diabetes of the young
OMIM:609812	maturity-onset diabetes of the young type 8

PubChem Disease

MedGen Diseases

Maturity-onset diabetes of the young type 8

OMIM Phenotypes

MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 8, WITH EXOCRINE DYSFUNCTION; MODY8

KEGG Diseases

Maturity onset diabetes of the young (MODY)

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001787
Gene Name: carboxyl ester lipase

Ortholog

Displaying entries **21 - 30** of 97 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Sarcophilus harrisii	100918682		SARHA14412
Pan paniscus	100969434	9597_0:002a25
Takifugu rubripes	101069939		TAKRU44283
Takifugu rubripes	101070169		TAKRU44283
Felis catus	101080585		FELCA30392
Ovis aries	101112299		SHEEP13333
Gorilla gorilla gorilla	101144373	9595_0:002bb8
Oryzias latipes	101172916		ORYLA02953
Mustela putorius furo	101674330		MUSPF11501
Ficedula albicollis	101806839		FICAL06155

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements