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cytochrome P450 family 21 subfamily A member 2

Summary

Gene Symbol

CYP21A2

Organism

Microcebus murinus (gray mouse lemur)

External Links

NCBI Gene: 105858145
KEGG Gene ID: mmur:105858145
PubChem: 105858145

Annotation

Keyword

Heme
Lipid metabolism
Monooxygenase
Steroid-binding
Transmembrane helix

Proteins

Displaying **all 6** entries
UniProt	Protein Name
A0A8B7EQS3	21-OHase Cytochrome P-450c21 Cytochrome P450 21 Cytochrome P450 XXI Cytochrome P450-C21
A0A8B7ENL7	21-OHase Cytochrome P-450c21 Cytochrome P450 21 Cytochrome P450 XXI Cytochrome P450-C21
A0A8B7ENL4	21-OHase Cytochrome P-450c21 Cytochrome P450 21 Cytochrome P450 XXI Cytochrome P450-C21
A0A8B7EQ61	21-OHase Cytochrome P-450c21 Cytochrome P450 21 Cytochrome P450 XXI Cytochrome P450-C21
A0A8B7EQS7	21-OHase Cytochrome P-450c21 Cytochrome P450 21 Cytochrome P450 XXI Cytochrome P450-C21
A0A8B7ENS5	21-OHase Cytochrome P-450c21 Cytochrome P450 21 Cytochrome P450 XXI Cytochrome P450-C21

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
organic acid metabolic process	IEA	30032202
xenobiotic metabolic process	IEA	30032202
hormone biosynthetic process	IEA	30032202
progesterone metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

hormone biosynthetic process

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

hormone biosynthetic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

small molecule metabolic process [inference]

organic acid metabolic process

cellular ketone metabolic process [inference]

progesterone metabolic process

organic substance metabolic process [inference]

organic acid metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular ketone metabolic process [inference]

progesterone metabolic process

olefinic compound metabolic process [inference]

progesterone metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

progesterone metabolic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

progesterone metabolic process

hormone biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytoplasm	IEA	30032202
intracellular membrane-bounded organelle	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
steroid 17-alpha-monooxygenase activity	IEA	30032202
iron ion binding	IEA	22301074
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA	30032202
heme binding	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

steroid hydroxylase activity [inference]

steroid 17-alpha-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cytochrome P450

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity