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structural maintenance of chromosomes 2

Summary

Gene Symbol

SMC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

10592

PubChem

10592

Alliance of Genome Resources

HGNC:14011

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Cell cycle
Chromosome
Coiled coil
Cytoplasm
DNA condensation
Mitosis
Nucleus
Reference proteome

Proteins

Displaying **all 8** entries
UniProt	Protein Name
Q7Z2X1
A8K984
Q05BV1
Q05D74
B3KMB1
Q6IPS5
O95347	Chromosome-associated protein E XCAP-E homolog
B7ZLZ7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
meiotic chromosome condensation	IEA
meiotic chromosome segregation	IEA
positive regulation of chromosome condensation	IDA ISS	17268547
positive regulation of chromosome segregation	ISO
positive regulation of chromosome separation	ISO

GO Hierarchy

biological process

cellular process [inference]

cell cycle process [inference]

chromosome segregation [inference]

nuclear chromosome segregation [inference]

meiotic chromosome segregation

meiotic cell cycle process [inference]

meiotic chromosome segregation

chromosome organization involved in meiotic cell cycle [inference]

meiotic chromosome condensation

mitotic cell cycle process [inference]

mitotic chromosome condensation

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

chromosome condensation [inference]

kinetochore organization

chromosome organization involved in meiotic cell cycle [inference]

meiotic chromosome condensation

reproductive process [inference]

meiotic cell cycle process [inference]

meiotic chromosome segregation

chromosome organization involved in meiotic cell cycle [inference]

meiotic chromosome condensation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of chromosome condensation

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of chromosome condensation

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of chromosome condensation

regulation of chromosome organization [inference]

regulation of chromosome condensation [inference]

positive regulation of chromosome condensation

positive regulation of chromosome organization [inference]

positive regulation of chromosome condensation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of chromosome condensation

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of chromosome segregation [inference]

positive regulation of chromosome segregation

regulation of chromosome separation [inference]

positive regulation of chromosome separation

positive regulation of cell cycle process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
condensed chromosome	IBA IDA	12589063
nuclear chromosome	IDA	10958694
nucleoplasm	IDA TAS
chromatin	IBA
condensin complex	IBA IDA NAS	10958694 11136719 17268547 9789013

GO Hierarchy

cellular component

protein-containing complex [inference]

condensin complex

protein-DNA complex [inference]

chromatin

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

nuclear chromosome

condensed nuclear chromosome

condensed chromosome

condensed nuclear chromosome

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

nuclear chromosome

condensed nuclear chromosome

condensed chromosome

condensed nuclear chromosome

nucleolus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12589063 17113138 17268547 21633354 23728299 26496610 30021884 33961781 35271311 9789013
chromatin binding	IBA
ATP hydrolysis activity	IEA
single-stranded DNA binding	IEA
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

single-stranded DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

structural maintenance of

Functional Category

C: Energy production and conversion
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
ATP binding

Displaying **all 6** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
RecF/RecN/SMC, N-terminal
SMCs flexible hinge superfamily
SMCs flexible hinge
Smc2, ATP-binding cassette domain
Structural maintenance of chromosomes protein

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:234	colon adenocarcinoma	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 88 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	850589		SGD:S000001927
Monodelphis domestica	100023190			MONDO29021
Equus caballus	100054338			HORSE24229
Ciona intestinalis	100180482			CIOIN10682
Taeniopygia guttata	100232341			TAEGU30864
Oryctolagus cuniculus	100339199			RABIT00057
Callithrix jacchus	100393356			CALJA18258
Pongo abelii	100435419	9601_0:0025ac		PONAB35435
Ailuropoda melanoleuca	100469876			AILME06574
Xenopus tropicalis	100486893		Xenbase:XB-GENE-5826169