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MIRAGE
pre-mRNA processing factor 8
Summary
- Gene Symbol
-
- PRPF8
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Direct protein sequencing
- Disease variant
- Methylation
- Nucleus
- Phosphoprotein
- RNA-binding
- Reference proteome
- Retinitis pigmentosa
- Ribonucleoprotein
- Spliceosome
- Proteins
| UniProt | Protein Name |
|---|---|
| Q6P2Q9 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| spliceosomal tri-snRNP complex assembly | ||
| spliceosomal tri-snRNP complex assembly | ||
| RNA splicing, via transesterification reactions | ||
| mRNA splicing, via spliceosome | ||
| mRNA splicing, via spliceosome |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| U2-type catalytic step 2 spliceosome | ||
| catalytic step 2 spliceosome | ||
| catalytic step 2 spliceosome |
| GO Term | Evidence Code | PMID |
|---|---|---|
| RNA binding | ||
| protein binding | ||
| peptidase activity | ||
| peptidase activity | ||
| U6 snRNA binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- pre-mRNA-processing-splicing factor
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| U1 snRNA binding |
| U2 snRNA binding |
| U5 snRNA binding |
| U6 snRNA binding |
| mRNA processing |
| metallopeptidase activity |
| pre-mRNA intronic binding |
| InterPro |
|---|
| Prp8 RNase domain IV, fingers region |
| Prp8 RNase domain IV, palm region |
| RNA recognition motif, spliceosomal PrP8 |
| Ribonuclease H-like superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110403 | retinitis pigmentosa 13 | |
| DOID:10584 | retinitis pigmentosa |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 101133153 | GORGO12618 | ||
| 101172750 | ORYLA03465 | ||
| 101320772 | TURTR07732 | ||
| 101576241 | OCTDE13571 | ||
| 101680023 | MUSPF15647 | ||
| 101724713 | HETGA11771 | ||
| 101805888 | FICAL07579 | ||
| 101874826 | MELUD09466 | ||
| 101925827 | MACFA12636 | ||
| 101946504 | CHRPI08713 |
