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PDZ and LIM domain 5

Summary

Gene Symbol

PDLIM5

Organism

Homo sapiens (human)

External Links

NCBI Gene

10611

PubChem

10611

Alliance of Genome Resources

HGNC:17468

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell projection
Cytoplasm
Direct protein sequencing
Isopeptide bond
LIM domain
Phosphoprotein
Reference proteome
Repeat
Synapse
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7Z8X5
Q96HC4	Enigma homolog Enigma-like PDZ and LIM domains protein
B7Z481

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
heart development	IBA
actin cytoskeleton organization	IBA
regulation of synapse assembly	ISS
regulation of dendritic spine morphogenesis	ISS
cell growth involved in cardiac muscle cell development	ISS

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell growth [inference]

developmental cell growth [inference]

cell growth involved in cardiac muscle cell development

actin filament-based process [inference]

actin cytoskeleton organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

heart development

muscle structure development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

cell growth involved in cardiac muscle cell development

developmental growth [inference]

developmental cell growth [inference]

cell growth involved in cardiac muscle cell development

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of dendritic spine morphogenesis

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendritic spine morphogenesis

regulation of synapse organization [inference]

regulation of synapse assembly

regulation of postsynapse organization [inference]

regulation of dendritic spine morphogenesis

regulation of cell junction assembly [inference]

regulation of synapse assembly

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
stress fiber	IBA
cytosol	ISS
adherens junction	IBA
adherens junction	HDA	25468996
postsynaptic density	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

filamentous actin

cellular anatomical entity [inference]

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

actomyosin [inference]

stress fiber

cell projection

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

postsynaptic specialization [inference]

postsynaptic density

presynapse

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GO Term	Evidence Code	PMID
actin binding	ISS
actin binding	IBA
protein kinase C binding	ISS
protein binding	IPI	16549780 25416956 31515488 32814053
actinin binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

actinin binding

alpha-actinin binding [inference]

muscle alpha-actinin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein kinase C binding

cell adhesion molecule binding [inference]

cadherin binding [inference]

cadherin binding involved in cell-cell adhesion

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity [inference]

cadherin binding involved in cell-cell adhesion

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

PDZ and LIM domain protein 5

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
actin binding
actin cytoskeleton organization
metal ion binding
muscle alpha-actinin binding
muscle structure development

Displaying **all 3** entries
InterPro
PDZ domain
PDZ superfamily
Zinc finger, LIM-type

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	9260	FB:FBgn0265991
Xenopus tropicalis	10611	Xenbase:XB-GENE-854114
Drosophila melanogaster	11155	FB:FBgn0265991
Drosophila melanogaster	24131	FB:FBgn0265991
Xenopus tropicalis	36740	Xenbase:XB-GENE-854114
Mus musculus	56376	Xenbase:XB-GENE-854114	MOUSE38472
Rattus norvegicus	64353	Xenbase:XB-GENE-854114	RATNO23818
Drosophila melanogaster	67399	FB:FBgn0265991
Drosophila melanogaster	286908	FB:FBgn0265991
Danio rerio	436927		DANRE35929