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HEXIM P-TEFb complex subunit 1

Summary

Gene Symbol

HEXIM1

Organism

Homo sapiens (human)

External Links

NCBI Gene

10614

KEGG Gene ID

PubChem

10614

Alliance of Genome Resources

HGNC:24953

Annotation

Keyword

3D-structure
Coiled coil
Cytoplasm
Innate immunity
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repressor
Transcription regulation

Proteins

Displaying 1 entry
UniProt	Protein Name
O94992	Cardiac lineage protein 1 Estrogen down-regulated gene 1 protein Hexamethylene bis-acetamide-inducible protein 1 Menage a quatre protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
negative regulation of transcription by RNA polymerase II	IMP
negative regulation of transcription by RNA polymerase II	IBA
negative regulation of transcription by RNA polymerase II	IEA
activation of innate immune response	IDA
heart development

GO Hierarchy

biological process

immune system process [inference]

activation of immune response [inference]

activation of innate immune response

immune response [inference]

innate immune response

developmental process [inference]

anatomical structure development [inference]

animal gross anatomical part developmental process [inference]

animal organ development [inference]

heart development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of signal transduction by p53 class mediator [inference]

positive regulation of signal transduction by p53 class mediator

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of viral process [inference]

negative regulation of viral transcription

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of signal transduction by p53 class mediator [inference]

positive regulation of signal transduction by p53 class mediator

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of viral process [inference]

regulation of viral transcription [inference]

negative regulation of viral transcription

negative regulation of viral process [inference]

negative regulation of viral transcription

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of signal transduction by p53 class mediator [inference]

positive regulation of signal transduction by p53 class mediator

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleus	EXP
nucleus	IDA
nucleus	IEA
nucleoplasm	IDA
nucleoplasm	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

Sm-like protein family complex [inference]

small nuclear ribonucleoprotein complex [inference]

7SK snRNP

nuclear protein-containing complex [inference]

small nuclear ribonucleoprotein complex [inference]

7SK snRNP

ribonucleoprotein complex [inference]

small nuclear ribonucleoprotein complex [inference]

7SK snRNP

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
protein kinase inhibitor activity	IDA
cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA
cyclin-dependent protein serine/threonine kinase inhibitor activity	IBA
cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA
protein binding	IPI