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replication factor C (activator 1) 4

Summary

Gene Symbol

Rfc4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

106344

PubChem

106344

Alliance of Genome Resources

MGI:2146571

Annotation

Keyword

ATP-binding
Acetylation
DNA replication
Direct protein sequencing
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q99J62	Activator 1 subunit 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
DNA-templated DNA replication	ISO
DNA-templated DNA replication	IBA
DNA repair	IBA
DNA duplex unwinding
positive regulation of DNA-directed DNA polymerase activity	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication [inference]

DNA-templated DNA replication

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

DNA conformation change [inference]

DNA geometric change [inference]

DNA duplex unwinding

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of transferase activity [inference]

positive regulation of transferase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleus	IBA
nucleoplasm	ISO
DNA replication factor C complex	ISO
DNA replication factor C complex	IBA
Ctf18 RFC-like complex	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

DNA replication factor C complex

nuclear protein-containing complex [inference]

Ctf18 RFC-like complex

catalytic complex [inference]

Elg1 RFC-like complex

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
DNA binding	IEA
DNA clamp loader activity	ISS
DNA clamp loader activity	ISO
DNA clamp loader activity	IBA
protein binding	IPI	32640224

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity [inference]

DNA helicase activity [inference]

single-stranded DNA helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

single-stranded DNA helicase activity

DNA clamp loader activity

binding [inference]

protein binding

enzyme binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity [inference]

DNA helicase activity [inference]

single-stranded DNA helicase activity

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

single-stranded DNA helicase activity

DNA clamp loader activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

replication factor

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
DNA repair
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ATPase, AAA-type, core
DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
P-loop containing nucleoside triphosphate hydrolase
Replication factor C, C-terminal
Replication factor C, lid domain

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements