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Guidelines

MIRAGE

CUGBP Elav-like family member 2

Summary

Gene Symbol

CELF2

Organism

Homo sapiens (human)

External Links

NCBI Gene

10659

PubChem

10659

Alliance of Genome Resources

HGNC:2550

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Disease variant
Epilepsy
Intellectual disability
Nucleus
Proteomics identification
RNA-binding
Reference proteome
Repeat
Repressor
mRNA processing

Proteins

Displaying **all 10** entries
UniProt	Protein Name
B4DZ01
O95319	Bruno-like protein 3 CUG triplet repeat RNA-binding protein 2 CUG-BP- and ETR-3-like factor 2 ELAV-type RNA-binding protein 3 Neuroblastoma apoptosis-related RNA-binding protein RNA-binding protein BRUNOL-3
E9PC62
A0A0J9YX66
B4DIB6
A0A1B0GUN8
A0A0J9YXJ0
B4DT00
B4DDE7
A0A1B0GU44

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
regulation of alternative mRNA splicing, via spliceosome	IBA
mRNA splice site recognition	IDA	11158314
mRNA splice site recognition	IBA
RNA processing	TAS	9887331
regulation of heart contraction	TAS	9887331

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

mRNA splice site recognition

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

mRNA splice site recognition

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

mRNA splice site recognition

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of RNA metabolic process [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
nucleus	IDA	11158314
nucleus	IMP	33131106
nucleus	IBA
nucleoplasm	IDA
cytoplasm	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle

nucleus

Flemming body

Displaying **all 3** entries
GO Term	Evidence Code	PMID
RNA binding	HDA	22681889
mRNA 3'-UTR binding	IBA
pre-mRNA binding	IDA	11158314

GO Hierarchy

molecular function

binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

mRNA binding [inference]

mRNA 3'-UTR binding

pre-mRNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cugbp elav-like family member

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
mRNA splice site recognition
regulation of alternative mRNA splicing, via spliceosome

Displaying **all 3** entries
InterPro
Nucleotide-binding alpha-beta plait domain superfamily
RNA recognition motif domain
RNA-binding domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070383	developmental and epileptic encephalopathy 97	Alliance of Genome Resources

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025