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UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

Summary

Gene Symbol

B3GNT2

Aliases

B3GN-T1
B3GN-T2
B3GNT-2
BETA3GNT

Organism

Homo sapiens (human)

External Links

NCBI Gene

10678

GGDB ID

gg116

HGNC

15629

mRNA

NM_006577

map

2p15

Protein

NP_006568

OMIM

605581

KEGG Gene ID

hsa:10678

PubChem

10678

Alliance of Genome Resources

HGNC:15629

Annotation

Keyword

3D-structure
Alternative splicing
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NY97	Beta-1,3-N-acetylglucosaminyltransferase 1 Beta-1,3-galactosyltransferase 7 Beta-3-Gx-T7 UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein O-linked glycosylation	IBA
poly-N-acetyllactosamine biosynthetic process	IBA IDA	11042166 25279697 9892646
axon guidance	IEA
sensory perception of smell	IEA
keratan sulfate biosynthetic process	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

poly-N-acetyllactosamine biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of smell

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to leukemia inhibitory factor [inference]

cellular response to leukemia inhibitory factor

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi membrane	IBA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	IBA IDA IEA TAS	11042166 25279697 9892646
protein binding	IPI	18826941
beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

galactosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

beta-1,3-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000170340

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg116

Gene Symbol

B3GNT2

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G00055MO	G29487JS	11042166

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Donor	Acceptor	Product	Reference
UDP-GlcNAc	G78941GA	G68257ZA	11042166
UDP-GlcNAc	G32723SL	G23438NR
UDP-GlcNAc	G18938DW	G79431NA	15620693
UDP-GlcNAc	G78059CC	G22865RK	15620693
UDP-GlcNAc	G00055MO	G29487JS	11042166 9892646
UDP-GlcNAc	G00049MO
UDP-GlcNAc	G58896AZ	G70874WW	11042166 11283017 9892646
UDP-GlcNAc	G46055MA	G25181AD	11283017
UDP-GlcNAc	G64973KT	G97494HI
UDP-GlcNAc	G00058MO	G73480MV	11283017

Displaying entries **1 - 10** of 28 in total

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Donor	Acceptor	Reference
UDP-GlcNAc	G09546QO	9892646
UDP-GlcNAc	G72002FC	11042166
UDP-GalNAc	G09546QO	9892646
UDP-GlcNAc	G00049MO	9892646
UDP-GlcNAc	G11457RF
UDP-Gal	G57321FI	9892646
UDP-GlcNAc	G57321FI	9892646
UDP-GalNAc	G68544GH	9892646
UDP-GlcNAc	G00035MO	9892646
UDP-GlcNAc	G68544GH	9892646

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_223674	XM_223674
Mus musculus	NP_058584	NM_016888

KEGG BRITE Database

Orthology

K00741

Name

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [EC:2.4.1.149]

References

11042166

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05974	2.4.1.149	G84034JH	G91404LJ
R05975	2.4.1.149	G58896AZ	G70874WW

Rhea

RHEA:14389

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + UDP-N-acetyl-α-D-glucosamine

an N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H⁺ + UDP

Enzyme

2.4.1.149

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 17 in total

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DO ID	Disease Name	Source
DOID:0050560	Walker-Warburg syndrome	DisGeNET
DOID:0111237	congenital muscular dystrophy-dystroglycanopathy type A1	DisGeNET
DOID:10283	prostate cancer	DisGeNET
DOID:10286	prostate carcinoma	DisGeNET
DOID:11847	coronary thrombosis	DisGeNET
DOID:12361	Graves' disease	DisGeNET
DOID:162	cancer	DisGeNET
DOID:2671	transitional cell carcinoma	DisGeNET
DOID:4398	pustulosis of palm and sole	DisGeNET
DOID:5419	schizophrenia	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001370
Gene Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178142	WB:WBGene00000270
Drosophila melanogaster	31358	FB:FBgn0000221
Callorhinchus milii	103177950		CALMI14201
Latimeria chalumnae	102359554		LATCH18025
Danio rerio	793362	ZFIN:ZDB-GENE-050913-158	DANRE11914
Danio rerio	405766	ZFIN:ZDB-GENE-090312-192
Astyanax mexicanus	103035833		ASTMX03267
Salmo trutta	115184140		SALTR90521
Salmo trutta	115193499		SALTR90521
Oryzias latipes	101168731		ORYLA04764

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements