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squalene epoxidase

Summary

Gene Symbol

SQLE

Organism

Equus asinus (ass)

External Links

NCBI Gene: 106839365
KEGG Gene ID: eai:106839365
PubChem: 106839365

Annotation

Keyword

Endoplasmic reticulum
FAD
Membrane
Oxidoreductase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A8C4MX83

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
sterol biosynthetic process	IEA	30032202
cholesterol metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IEA	30032202
membrane	IEA	22301074

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
flavin adenine dinucleotide binding	IEA	22301074
squalene monooxygenase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

squalene monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

squalene monooxygenase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00511

Name

squalene monooxygenase [EC:1.14.14.17]

References

17852349

Rhea

O₂ + squalene

H₂O + H⁺ + (S)-2,3-epoxysqualene

Enzyme

1.14.14.17

PMID

Ortholog

Displaying entries **51 - 60** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Bos indicus x Bos taurus	113904114		BOBOX30426
Otolemur garnettii	100943926		OTOGA18032
Chinchilla lanigera	102028063		CHILA15439
Saimiri boliviensis boliviensis	101054084		SAIBB22744
Ictidomys tridecemlineatus	101958808		ICTTR09409
Jaculus jaculus	101599377		JACJA12905
Myotis lucifugus	102420731		MYOLU03480
Rhinolophus ferrumequinum	117033653		RHIFE05189
Taeniopygia guttata	100225604		TAEGU18523
Ficedula albicollis	101806873		FICAL02801

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024