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corin, serine peptidase

Summary

Gene Symbol

CORIN

Organism

Homo sapiens (human)

External Links

NCBI Gene

10699

PubChem

10699

Alliance of Genome Resources

HGNC:19012

Annotation

Keyword

Alternative splicing
Autocatalytic cleavage
Cardiomyopathy
Cell membrane
Disulfide bond
Glycoprotein
Proteomics identification
Reference proteome
Repeat
Secreted
Serine protease
Signal-anchor
Transmembrane helix
Zymogen

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q9Y5Q5	Corin Heart-specific serine proteinase ATC2 Pro-ANP-converting enzyme Transmembrane protease serine 10
A0A087X1D5
B4E1Y7
B4E2W9
J3KR83

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
regulation of systemic arterial blood pressure by atrial natriuretic peptide	ISS
regulation of systemic arterial blood pressure by atrial natriuretic peptide	IMP	22437503
female pregnancy	IMP	22437503
regulation of blood pressure	ISS
peptide hormone processing	IDA	10880574 21518754

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

hormone metabolic process [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by atrial natriuretic peptide

multi-multicellular organism process [inference]

female pregnancy

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of excretion [inference]

regulation of renal sodium excretion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of excretion [inference]

regulation of renal sodium excretion

regulation of renal system process [inference]

regulation of renal sodium excretion

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of cardiac conduction

regulation of biological quality [inference]

regulation of blood pressure

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of systemic arterial blood pressure by atrial natriuretic peptide

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
plasma membrane	TAS
plasma membrane	IDA	21518754
plasma membrane	IBA
cell surface	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

nuclear body

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endopeptidase activity	IMP	20489134
serine-type endopeptidase activity	TAS
serine-type endopeptidase activity	IDA	10880574 21518754 21763278
protein binding	IPI	32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transmembrane protease serine

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
proteolysis
serine-type endopeptidase activity

Displaying **all 4** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Serine proteases, trypsin domain
Serine proteases, trypsin family, serine active site

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080326	familial hypertrophic cardiomyopathy	Alliance of Genome Resources
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10699	Xenbase:XB-GENE-950958
Mus musculus	53419	Xenbase:XB-GENE-950958	MOUSE43466
Rattus norvegicus	289596	Xenbase:XB-GENE-950958	RATNO08211
Macaca mulatta	704666		MACMU37455
Pan troglodytes	740125		PANTR34030
Monodelphis domestica	100019479		MONDO27767
Equus caballus	100054484		HORSE30339
Taeniopygia guttata	100231807		TAEGU23223
Oryctolagus cuniculus	100340894		RABIT08044
Callithrix jacchus	100397961		CALJA29802

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UniCarb-DR

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements