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cholesteryl ester transfer protein

Summary

Gene Symbol

CETP

Organism

Homo sapiens (human)

External Links

NCBI Gene

1071

PubChem

1071

Alliance of Genome Resources

HGNC:1869

Annotation

Keyword

3D-structure
Alternative splicing
Atherosclerosis
Cholesterol metabolism
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Lipid transport
Reference proteome
Secreted
Signal

Proteins

Displaying **all 4** entries
UniProt	Protein Name
P11597	Lipid transfer protein I
A0A0S2Z3F6	Lipid transfer protein I
A0A0S2Z3I8	Lipid transfer protein I
B4DMZ5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
triglyceride metabolic process	IDA	2833496
triglyceride metabolic process	IBA
lipid transport	IDA	3818596
cholesterol metabolic process	IDA	2833496
cholesterol metabolic process	IMP	2586614

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

very-low-density lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

very-low-density lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

very-low-density lipoprotein particle remodeling

multicellular organismal process [inference]

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

triglyceride-rich lipoprotein particle remodeling [inference]

very-low-density lipoprotein particle remodeling

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis

acylglycerol homeostasis [inference]

triglyceride homeostasis

phospholipid homeostasis

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport

phospholipid transport

sterol transport [inference]

cholesterol transport

reverse cholesterol transport

acylglycerol transport [inference]

triglyceride transport

organophosphate ester transport [inference]

phospholipid transport

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport

reverse cholesterol transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of cholesterol transport [inference]

regulation of phospholipid transport [inference]

positive regulation of phospholipid transport

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of cholesterol transport [inference]

regulation of phospholipid transport [inference]

positive regulation of phospholipid transport

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

regulation of cellular process [inference]

regulation of cell differentiation [inference]

regulation of macrophage derived foam cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of macrophage derived foam cell differentiation

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	24293641 3104518
vesicle	IDA	2833496
high-density lipoprotein particle	IDA	3104518
high-density lipoprotein particle	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

high-density lipoprotein particle

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
phospholipid transporter activity	IDA	2833496
phospholipid transporter activity	IBA
lipid binding	IDA	3818596
cholesterol binding	IDA	2833496
cholesterol binding	IBA

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity

sterol transporter activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

lipid transfer activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

binding [inference]

lipid binding

steroid binding [inference]

sterol binding [inference]

cholesterol binding

phospholipid binding [inference]

phosphatidylcholine binding

triglyceride binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

ion binding [inference]

cation binding [inference]

phosphatidylcholine binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cholesteryl ester transfer protein

Functional Category

C: Energy production and conversion
K: Transcription
T: Signal transduction mechanisms

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Gene Ontology
cholesterol binding
cholesterol metabolic process
high-density lipoprotein particle remodeling
intermembrane lipid transfer
lipid binding
lipid metabolic process
lipid transport
low-density lipoprotein particle remodeling
phosphatidylcholine binding
phosphatidylcholine metabolic process

Displaying **all 4** entries
InterPro
Bactericidal permeability-increasing protein, alpha/beta domain superfamily
Cholesteryl ester transfer
Lipid-binding serum glycoprotein, C-terminal
Lipid-binding serum glycoprotein, N-terminal

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111369	hyperalphalipoproteinemia 1	Alliance of Genome Resources
DOID:3407	carotid artery disease	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1071	Xenbase:XB-GENE-922348
Pan troglodytes	467982		PANTR12430
Danio rerio	492488		DANRE13791
Macaca mulatta	710267		MACMU26849
Monodelphis domestica	100021113		MONDO08087
Taeniopygia guttata	100228043		TAEGU03269
Oryctolagus cuniculus	100327267		RABIT10891
Callithrix jacchus	100410300		CALJA21214
Pongo abelii	100435719		PONAB10817
Meleagris gallopavo	100541061		MELGA03413

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