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neuregulin 3

Summary

Gene Symbol

NRG3

Organism

Homo sapiens (human)

External Links

NCBI Gene

10718

PubChem

10718

Alliance of Genome Resources

HGNC:7999

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Reference proteome
Secreted
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B9EGV5
P56975
B3KVG8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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3

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GO Term	Evidence Code	PMID
synapse assembly	IEA
animal organ development	IBA
ERBB4-ERBB4 signaling pathway	IEA
pattern specification process	IEA
mammary placode formation	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

ERBB4 signaling pathway

ERBB4-ERBB4 signaling pathway

intracellular signal transduction

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

multicellular organismal process [inference]

pattern specification process

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

ectodermal placode formation [inference]

mammary placode formation

anatomical structure development [inference]

animal organ development

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis [inference]

chemorepulsion involved in interneuron migration from the subpallium to the cortex

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of growth [inference]

regulation of cell growth

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

regulation of neuron migration [inference]

negative regulation of neuron migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

ERBB4 signaling pathway

ERBB4-ERBB4 signaling pathway

intracellular signal transduction

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

regulation of cellular component organization [inference]

regulation of cell growth

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

regulation of neuron migration [inference]

negative regulation of neuron migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of neuron migration

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	NAS	9275162
extracellular region	NAS	9275162
extracellular space	IBA IDA	12466964
glutamatergic synapse	IDA IMP	29114105

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

Displaying **all 5** entries
GO Term	Evidence Code	PMID
receptor ligand activity	IDA	12466964
chemorepellent activity	IBA
transmembrane receptor protein tyrosine kinase activator activity	NAS	9275162
growth factor activity	NAS	9275162
receptor tyrosine kinase binding	NAS	9275162

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor tyrosine kinase binding

receptor ligand activity

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

receptor ligand activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

signaling receptor activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Pro-neuregulin-3, membrane-bound isoform

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
animal organ development
chemorepellent activity
growth factor activity
nervous system development
signaling receptor binding

Displaying 1 entry
InterPro
Neuregulin

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:5419	schizophrenia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 29 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	18183		MGI:1097165	MOUSE14298
Pan troglodytes	466296	9598_0:002c65		PANTR01026
Rattus norvegicus	498596		RGD:1559678	RATNO10765
Macaca mulatta	699268			MACMU46142
Xenopus tropicalis	100125039		Xenbase:XB-GENE-984146
Callithrix jacchus	100387417			CALJA05945
Pongo abelii	100460909	9601_0:0029a0		PONAB01873
Pan paniscus	100980498	9597_0:002af9		PANPA05044
Papio anubis	101012038			PAPAN03012
Saimiri boliviensis boliviensis	101037689			SAIBB36713

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024