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Guidelines

MIRAGE

golgi-specific brefeldin A-resistance factor 1

Summary

Gene Symbol

Gbf1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

107338

PubChem

107338

Alliance of Genome Resources

MGI:1861607

Annotation

Keyword

Cytoplasm
Golgi apparatus
Guanine-nucleotide releasing factor
Lipid droplet
Membrane
Phosphoprotein
Protein transport
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6DFZ1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 36 in total

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GO Term	Evidence Code	PMID
Golgi to endosome transport	IEA
Golgi organization	ISO
regulation of mitotic cell cycle	ISO
regulation of mitotic cell cycle	IEA
protein transport	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

metabolic process [inference]

biosynthetic process [inference]

reactive oxygen species biosynthetic process

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

reactive oxygen species biosynthetic process

cellular process [inference]

cell activation [inference]

cell activation involved in immune response

establishment or maintenance of cell polarity [inference]

establishment of cell polarity [inference]

establishment of monopolar cell polarity

establishment or maintenance of monopolar cell polarity [inference]

establishment of monopolar cell polarity

vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

Golgi vesicle transport [inference]

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

post-Golgi vesicle-mediated transport [inference]

Golgi to endosome transport

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

reactive oxygen species biosynthetic process

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

protein localization to endoplasmic reticulum [inference]

establishment of protein localization [inference]

protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

Golgi organization

Golgi disassembly

vesicle organization [inference]

vesicle coating [inference]

Golgi transport vesicle coating [inference]

COPI coating of Golgi vesicle

endoplasmic reticulum-Golgi intermediate compartment organization

organelle disassembly [inference]

Golgi disassembly

cellular component disassembly [inference]

organelle disassembly [inference]

Golgi disassembly

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

cellular response to virus

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

cellular response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

cellular response to virus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

protein localization to endoplasmic reticulum [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

Golgi vesicle transport [inference]

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

post-Golgi vesicle-mediated transport [inference]

Golgi to endosome transport

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

protein localization to endoplasmic reticulum [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of ARF protein signal transduction

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to cell surface

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of ARF protein signal transduction

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of ARF protein signal transduction

regulation of cell cycle [inference]

regulation of mitotic cell cycle

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to cell surface

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IEA
peroxisome	ISO
peroxisome	IEA
endoplasmic reticulum lumen	ISO
endoplasmic reticulum lumen	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

cell leading edge

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular non-membrane-bounded organelle [inference]

lipid droplet

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	IEA
protein binding	IPI	12634853
phosphatidylinositol-3,4,5-trisphosphate binding	ISO
phosphatidylinositol-3,4,5-trisphosphate binding	IEA
phosphatidylinositol-3,5-bisphosphate binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-3,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of ARF protein signal transduction

Displaying **all 5** entries
InterPro
Armadillo-type fold
Mon2/Sec7/BIG1-like, HUS domain
Sec7 domain superfamily
Sec7 domain
Sec7, C-terminal domain superfamily

Ortholog

Displaying entries **1 - 10** of 91 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8729	Xenbase:XB-GENE-1012128	HUMAN02665
Xenopus tropicalis	107338	Xenbase:XB-GENE-1012128
Rattus norvegicus	309451		RATNO20380
Pan troglodytes	466190		PANTR01437
Canis lupus familiaris	486857		CANLF11422
Bos taurus	533207		BOVIN21417
Danio rerio	566350		DANRE05395
Macaca mulatta	714579		MACMU46075
Monodelphis domestica	100023096		MONDO07170
Ornithorhynchus anatinus	100080060		ORNAN08203

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Last updated: March 31, 2025