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adenosylhomocysteinase like 1

Summary

Gene Symbol

AHCYL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

10768

PubChem

10768

Alliance of Genome Resources

HGNC:344

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell membrane
Cytoplasm
Hydrolase
Microsome
NAD
One-carbon metabolism
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A024R0A8
O43865	DC-expressed AHCY-like molecule IP(3)Rs binding protein released with IP(3) Putative adenosylhomocysteinase 2 S-adenosyl-L-homocysteine hydrolase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
protein export from nucleus	IEA
one-carbon metabolic process	IEA
apoptotic process	IMP	27995898
positive regulation of sodium ion transport	IMP	16769890
regulation of mRNA 3'-end processing	IDA	19224921

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

one-carbon metabolic process

sulfur compound metabolic process [inference]

S-adenosylmethionine metabolic process [inference]

S-adenosylmethionine cycle

small molecule metabolic process [inference]

one-carbon metabolic process

organic substance metabolic process [inference]

S-adenosylmethionine metabolic process [inference]

S-adenosylmethionine cycle

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

angiotensin-activated signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

membrane docking [inference]

organelle localization by membrane tethering [inference]

mitochondrion-endoplasmic reticulum membrane tethering

cellular metabolic process [inference]

one-carbon metabolic process

sulfur compound metabolic process [inference]

S-adenosylmethionine metabolic process [inference]

S-adenosylmethionine cycle

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

mitochondrion-endoplasmic reticulum membrane tethering

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion

response to salt [inference]

response to calcium ion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

establishment of localization [inference]

transport [inference]

fluid transport [inference]

epithelial fluid transport

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

transepithelial transport [inference]

epithelial fluid transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

organelle localization [inference]

organelle localization by membrane tethering [inference]

mitochondrion-endoplasmic reticulum membrane tethering

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

protein export from nucleus

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein export from nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA 3'-end processing

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA 3'-end processing

regulation of macromolecule metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA 3'-end processing

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA 3'-end processing

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of ion transmembrane transporter activity

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of sodium ion transport [inference]

positive regulation of sodium ion transport

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

regulation of monoatomic anion transport

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

angiotensin-activated signaling pathway

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA 3'-end processing

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of ion transmembrane transporter activity

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of ion transmembrane transporter activity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISS
endoplasmic reticulum membrane	TAS
cytosol	IBA
apical plasma membrane	ISS
mitochondria-associated endoplasmic reticulum membrane	IDA	27995898

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

organelle membrane contact site [inference]

mitochondria-associated endoplasmic reticulum membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
RNA binding	IEA
adenosylhomocysteinase activity	IBA
protein binding	IPI	16769890 16793548 18829453 19220705 19224921 20584908 22190034 25416956 25910212 26871637 27995898 28514442 29513927 31046837 31515488 32296183 32814053 33961781 35156780 36012204
enzyme regulator activity	IEA
identical protein binding	IPI	25416956 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-sulfur bonds [inference]

adenosylhomocysteinase activity

binding [inference]

protein binding

identical protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

molecular function regulator activity [inference]

enzyme regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

adenosylhomocysteinase A

Functional Category

E: Amino acid transport and metabolism
H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 3** entries
Gene Ontology
S-adenosylmethionine cycle
adenosylhomocysteinase activity
hydrolase activity

Displaying **all 5** entries
InterPro
Adenosylhomocysteinase-like superfamily
Adenosylhomocysteinase-like
NAD(P)-binding domain superfamily
S-adenosyl-L-homocysteine hydrolase, NAD binding domain
S-adenosyl-L-homocysteine hydrolase, conserved site