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Submissions

methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase

Summary

Gene Symbol

Mthfd1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

108156

PubChem

108156

Alliance of Genome Resources

MGI:1342005

Annotation

Keyword

ATP-binding
Acetylation
Cytoplasm
Direct protein sequencing
Histidine biosynthesis
Hydrolase
Ligase
Methionine biosynthesis
Multifunctional enzyme
NADP
One-carbon metabolism
Oxidoreductase
Phosphoprotein
Purine biosynthesis
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q8BXX7
Q922D8
Q3TW74

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

1

2

3

4

5

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Last »
GO Term	Evidence Code	PMID
histidine biosynthetic process
neutrophil homeostasis	IMP	23704330
neural tube closure	IMP	23704330
purine nucleotide biosynthetic process	ISO
purine nucleotide biosynthetic process	IMP	23704330

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid metabolic process

cysteine metabolic process [inference]

transsulfuration

serine family amino acid biosynthetic process

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid metabolic process

cysteine metabolic process [inference]

transsulfuration

serine family amino acid biosynthetic process

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

one-carbon metabolic process

tetrahydrofolate interconversion

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid metabolic process

cysteine metabolic process [inference]

transsulfuration

serine family amino acid biosynthetic process

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid metabolic process

cysteine metabolic process [inference]

transsulfuration

serine family amino acid biosynthetic process

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

one-carbon metabolic process

tetrahydrofolate interconversion

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid metabolic process

cysteine metabolic process [inference]

transsulfuration

serine family amino acid biosynthetic process

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid metabolic process

cysteine metabolic process [inference]

transsulfuration

serine family amino acid biosynthetic process

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid metabolic process

cysteine metabolic process [inference]

transsulfuration

serine family amino acid biosynthetic process

homoserine metabolic process [inference]

transsulfuration

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid metabolic process [inference]

10-formyltetrahydrofolate metabolic process [inference]

10-formyltetrahydrofolate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

one-carbon metabolic process

tetrahydrofolate interconversion

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cysteine metabolic process [inference]

transsulfuration

methionine metabolic process

methionine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

organophosphate biosynthetic process [inference]

ribose phosphate biosynthetic process [inference]

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

serine family amino acid biosynthetic process

dicarboxylic acid biosynthetic process [inference]

10-formyltetrahydrofolate biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

ribonucleotide biosynthetic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process [inference]

tetrahydrofolate interconversion

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

purine ribonucleotide metabolic process [inference]

purine ribonucleotide biosynthetic process

purine-containing compound biosynthetic process [inference]

purine nucleotide biosynthetic process

purine ribonucleotide biosynthetic process

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

somite development

animal organ development [inference]

heart development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitochondrion	HDA	14651853 18614015
cytosol	ISO
cytosol	IDA	15611115 16150419
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

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GO Term	Evidence Code	PMID
formate-tetrahydrofolate ligase activity	ISO
formate-tetrahydrofolate ligase activity	IMP	15611115 23704330
methenyltetrahydrofolate cyclohydrolase activity	ISS
methenyltetrahydrofolate cyclohydrolase activity	ISO
methenyltetrahydrofolate cyclohydrolase activity	IGI	16150419

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-NH group of donors [inference]

oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [inference]

methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [inference]

cyclohydrolase activity [inference]

methenyltetrahydrofolate cyclohydrolase activity

ligase activity [inference]

ligase activity, forming carbon-nitrogen bonds [inference]

formate-tetrahydrofolate ligase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

C-1-tetrahydrofolate synthase, cytoplasmic

Functional Category

E: Amino acid transport and metabolism
F: Nucleotide transport and metabolism
H: Coenzyme transport and metabolism

Displaying **all 6** entries
Gene Ontology
ATP binding
catalytic activity
formate-tetrahydrofolate ligase activity
methenyltetrahydrofolate cyclohydrolase activity
methylenetetrahydrofolate dehydrogenase (NADP+) activity
tetrahydrofolate interconversion

Displaying **all 8** entries
InterPro
Aminoacid dehydrogenase-like, N-terminal domain superfamily
Formate-tetrahydrofolate ligase, FTHFS, conserved site
Formate-tetrahydrofolate ligase, FTHFS
NAD(P)-binding domain superfamily
P-loop containing nucleoside triphosphate hydrolase
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
Tetrahydrofolate dehydrogenase/cyclohydrolase

Rhea

RHEA:20221

formate + ATP + (6S)-5,6,7,8-tetrahydrofolate

(6R)-10-formyltetrahydrofolate + phosphate + ADP

Enzyme

6.3.4.3

PMID

RHEA:22812

(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP⁺

(6R)-5,10-methenyltetrahydrofolate + NADPH

Enzyme

1.5.1.5

PMID

RHEA:23700

H₂O + (6R)-5,10-methenyltetrahydrofolate

H⁺ + (6R)-10-formyltetrahydrofolate

Enzyme

3.5.4.9

PMID

13672973

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4522	Xenbase:XB-GENE-992132	HUMAN19779
Saccharomyces cerevisiae S288C	25902	SGD:S000003436
Rattus norvegicus	64300		RATNO36666
Xenopus tropicalis	108156	Xenbase:XB-GENE-992132
Danio rerio	260441		DANRE12930
Sus scrofa	414382		PIGXX32673
Pan troglodytes	452965		PANTR08945
Bos taurus	534382		BOVIN01543
Rattus norvegicus	680432		RATNO36666
Macaca mulatta	707059		MACMU42509

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements