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Guidelines

MIRAGE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

Summary

Gene Symbol

GNE

Organism

Rhinopithecus bieti (black snub-nosed monkey)

External Links

NCBI Gene: 108542566
KEGG Gene ID: rbb:108542566
PubChem: 108542566

Annotation

Keyword

ATP-binding
Allosteric enzyme
Cytoplasm
Hydrolase
Kinase
Metal-binding
Multifunctional enzyme
Phosphoprotein
Reference proteome
Zinc

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0AAJ7MZ37	UDP-GlcNAc-2-epimerase/ManAc kinase
A0A2K6KNC5	UDP-GlcNAc-2-epimerase/ManAc kinase
A0A2K6KNB4	UDP-GlcNAc-2-epimerase/ManAc kinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
UDP-N-acetylglucosamine metabolic process	IEA	22301074

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

phosphorus metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

organic substance metabolic process [inference]

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

phosphorus metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
hydrolase activity, hydrolyzing O-glycosyl compounds	IEA	22301074
UDP-N-acetylglucosamine 2-epimerase activity	IEA	30032202
N-acylmannosamine kinase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

carbohydrate kinase activity [inference]

N-acylmannosamine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

N-acylmannosamine kinase activity

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

isomerase activity [inference]

racemase and epimerase activity [inference]

racemase and epimerase activity, acting on carbohydrates and derivatives [inference]

UDP-N-acetylglucosamine 2-epimerase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K12409

Name

bifunctional UDP-N-acetylglucosamine 2-epimerase / N-acetylmannosamine kinase [EC:3.2.1.183 2.7.1.60]

References

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026