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ADAM metallopeptidase domain 28
Summary
- Gene Symbol
-
- ADAM28
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative splicing
- Cell membrane
- Cleavage on pair of basic residues
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Hydrolase
- Membrane
- Metal-binding
- Metalloprotease
- Reference proteome
- Secreted
- Signal
- Transmembrane helix
- Zinc
- Zymogen
- Proteins
| UniProt | Protein Name |
|---|---|
| Q9UKQ2 |
|
| A0A384NKT9 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| spermatogenesis |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| mitochondrion | ||
| plasma membrane | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| metalloendopeptidase activity | ||
| protein binding | ||
| metallopeptidase activity | ||
| immunoglobulin receptor binding | ||
| metal ion binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Disintegrin
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| metal ion binding |
| metalloendopeptidase activity |
| metallopeptidase activity |
| proteolysis |
| InterPro |
|---|
| ADAM, cysteine-rich domain |
| Disintegrin domain superfamily |
| Disintegrin domain |
| Metallopeptidase, catalytic domain superfamily |
| Peptidase M12B, ADAM/reprolysin |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060075 | estrogen-receptor positive breast cancer | |
| DOID:1612 | breast cancer | |
| DOID:3008 | invasive ductal carcinoma | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:3910 | lung adenocarcinoma |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 101 | FB:FBgn0265140 | ||
| 8038 | FB:FBgn0265140 | ||
| 8728 | FB:FBgn0265140 | ||
| 8751 | FB:FBgn0265140 | ||
| 8754 | FB:FBgn0265140 | ||
| 8756 | Xenbase:XB-GENE-982024 | ||
| 10863 | Xenbase:XB-GENE-982024 | ||
| 11085 | FB:FBgn0265140 | ||
| 11489 | FB:FBgn0265140 | ||
| 11490 | FB:FBgn0265140 |
