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ER degradation enhancer, mannosidase alpha-like 2

Summary

Gene Symbol

Edem2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

108687

PubChem

108687

Alliance of Genome Resources

MGI:1915540

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Reference proteome
Signal
Unfolded protein response

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8BJT9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 7** of 7 in total

« First

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2
GO Term	Evidence Code	PMID
endoplasmic reticulum mannose trimming	IBA
positive regulation of retrograde protein transport, ER to cytosol	IDA ISO	24200403

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

mannoprotein catabolic process

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

mannoprotein catabolic process

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

mannoprotein catabolic process

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

macromolecule modification [inference]

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

mannoprotein catabolic process

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

glycoprotein metabolic process [inference]

mannoprotein metabolic process [inference]

mannoprotein catabolic process

glycoprotein catabolic process [inference]

mannoprotein catabolic process

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process [inference]

mannoprotein catabolic process

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to topologically incorrect protein [inference]

response to unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to topologically incorrect protein [inference]

response to unfolded protein

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen
endoplasmic reticulum	IBA ISO
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IEA
calcium ion binding	IEA
protein binding	IPI	24200403

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

mannosidase activity [inference]

alpha-mannosidase activity [inference]

mannosyl-oligosaccharide mannosidase activity [inference]

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	179653	WB:WBGene00008646
Drosophila melanogaster	31154	FB:FBgn0023511
Ciona intestinalis	100175549		CIOIN02154
Callorhinchus milii	103189915		CALMI42557
Latimeria chalumnae	102367625		LATCH19860
Danio rerio	402801	ZFIN:ZDB-GENE-060519-1	DANRE25012
Astyanax mexicanus	103022382		ASTMX15294
Ictalurus punctatus	108276291		ICTPU07537
Electrophorus electricus	113583115		ELEEL31275
Salmo trutta	115165953		SALTR88502

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Last updated: August 19, 2024