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cleavage and polyadenylation specific factor 4

Summary

Gene Symbol

CPSF4

Organism

Homo sapiens (human)

External Links

NCBI Gene

10898

PubChem

10898

Alliance of Genome Resources

HGNC:2327

Annotation

Keyword

3D-structure
Alternative splicing
Host-virus interaction
Nucleus
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Repeat
Zinc-finger
mRNA processing

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O95639	Cleavage and polyadenylation specificity factor 30 kDa subunit NS1 effector domain-binding protein 1 No arches homolog
B7Z7B0	Cleavage and polyadenylation specificity factor 30 kDa subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
mRNA processing	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleoplasm	TAS
nucleoplasm	IDA
mRNA cleavage and polyadenylation specificity factor complex	IDA	21102410
mRNA cleavage and polyadenylation specificity factor complex	IBA
intracellular membrane-bounded organelle	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

mRNA cleavage factor complex [inference]

mRNA cleavage and polyadenylation specificity factor complex

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
RNA binding	HDA	22681889
protein binding	IPI	16189514 18725644 19136632 25416956 26496610 28169297 32296183 33961781
zinc ion binding	IEA
sequence-specific double-stranded DNA binding	IDA	28473536

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cleavage and polyadenylation specificity factor

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
mRNA 3'-end processing
mRNA processing
metal ion binding
obsolete pre-mRNA cleavage required for polyadenylation

Displaying **all 3** entries
InterPro
CPSF complex subunit CPSF4-like
Zinc finger, CCCH-type superfamily
Zinc finger, CCCH-type

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10898	Xenbase:XB-GENE-948302
Danio rerio	30203		DANRE31310
Mus musculus	54188		MOUSE43750
Bos taurus	280875		BOVIN20937
Rattus norvegicus	304277		RATNO05888
Pan troglodytes	463572		PANTR40853
Canis lupus familiaris	489859		CANLF16251
Monodelphis domestica	100011934		MONDO31017
Equus caballus	100059364		HORSE07653
Ornithorhynchus anatinus	100081275		ORNAN15153