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3-hydroxy-3-methylglutaryl-CoA lyase like 1

Summary

Gene Symbol

HMGCLL1

Organism

Panthera pardus (leopard)

External Links

NCBI Gene: 109271779
KEGG Gene ID: ppad:109271779
PubChem: 109271779

Annotation

Keyword

Lyase
Metal-binding

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A9V1G0V8
A0A9V1G0Z2
A0A9V1G0U3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
leucine catabolic process	IEA	30032202
ketone body biosynthetic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

ketone body biosynthetic process

small molecule biosynthetic process [inference]

ketone body biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

generation of precursor metabolites and energy [inference]

ketone body metabolic process [inference]

ketone body biosynthetic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

cellular biosynthetic process [inference]

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

ketone body metabolic process [inference]

ketone body biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

small molecule biosynthetic process [inference]

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

ketone body metabolic process [inference]

ketone body biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

branched-chain amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid metabolic process [inference]

leucine metabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

generation of precursor metabolites and energy [inference]

ketone body metabolic process [inference]

ketone body biosynthetic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

leucine catabolic process

alpha-amino acid catabolic process [inference]

leucine catabolic process

cellular biosynthetic process [inference]

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IEA	30032202
cytosol	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying 1 entry
GO Term	Evidence Code	PMID
hydroxymethylglutaryl-CoA lyase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

oxo-acid-lyase activity [inference]

hydroxymethylglutaryl-CoA lyase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Carnivora

Group Name

3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic

Functional Category

E: Amino acid transport and metabolism
H: Coenzyme transport and metabolism
I: Lipid transport and metabolism

Displaying **all 7** entries
Gene Ontology
catalytic activity
hydroxymethylglutaryl-CoA lyase activity
ketone body biosynthetic process
leucine catabolic process
lyase activity
metal ion binding
oxo-acid-lyase activity

Displaying **all 3** entries
InterPro
Aldolase-type TIM barrel
HMG-CoA lyase
Pyruvate carboxyltransferase

KEGG BRITE Database

Orthology

K01640

Name

hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]

References

17692550

Rhea

(3S)-hydroxy-3-methylglutaryl-CoA

acetoacetate + acetyl-CoA

Enzyme

4.1.3.4

PMID

Ortholog

Displaying entries **1 - 10** of 42 in total

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Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Canis lupus familiaris	481852	9615_1:00253c
Ailuropoda melanoleuca	100482170	9646_0:004762
Felis catus	101088750	9685_0:00171e
Mustela putorius furo	101673363	9669_0:004828
Leptonychotes weddellii	102726050	9713_0:0003cc
Panthera tigris	102965458	9694_0:00159f
Ursus maritimus	103663985	29073_0:00362c
Acinonyx jubatus	106973083	32536_0:0023ca
Neomonachus schauinslandi	110582107	29088_0:002931
Enhydra lutris kenyoni	111152335	391180_0:002905

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Last updated: December 9, 2024