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activating signal cointegrator 1 complex subunit 3

Summary

Gene Symbol

ASCC3

Organism

Homo sapiens (human)

External Links

NCBI Gene

10973

PubChem

10973

Alliance of Genome Resources

HGNC:18697

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Coiled coil
Cytoplasm
DNA repair
Direct protein sequencing
Helicase
Intellectual disability
Nucleus
Phosphoprotein
Reference proteome
Repeat
Transcription regulation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8N3C0	ASC-1 complex subunit p200 Helicase, ATP binding 1 Trip4 complex subunit p200
B4DR60

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
DNA dealkylation involved in DNA repair	NAS	29997253
DNA dealkylation involved in DNA repair	IDA	22055184
DNA duplex unwinding
ribosome disassembly	NAS	32099016
ribosome disassembly	IDA	32579943 36302773

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

macromolecule modification [inference]

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process [inference]

ribosome-associated ubiquitin-dependent protein catabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translational elongation [inference]

rescue of stalled ribosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

DNA conformation change [inference]

DNA geometric change [inference]

DNA duplex unwinding

organelle disassembly [inference]

ribosome disassembly

rescue of stalled ribosome

cellular component disassembly [inference]

organelle disassembly [inference]

ribosome disassembly

rescue of stalled ribosome

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleus	TAS	22055184
nucleus	IDA	12077347 29997253
nucleus	IBA
nucleoplasm	TAS
cytosol	IDA	28757607

GO Hierarchy

cellular component

protein-containing complex [inference]

transcription regulator complex [inference]

RNA polymerase II transcription regulator complex [inference]

activating signal cointegrator 1 complex

nuclear protein-containing complex [inference]

RNA polymerase II transcription regulator complex [inference]

activating signal cointegrator 1 complex

RQC-trigger complex

catalytic complex [inference]

DNA repair complex

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribosome [inference]

cytosolic ribosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

ribosome [inference]

cytosolic ribosome

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22681889
protein binding	IPI	22055184 28514442 29997253 33961781
ATP binding	IEA
four-way junction helicase activity	IEA
ATP hydrolysis activity	IDA	32579943 36302773

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity [inference]

DNA helicase activity [inference]

four-way junction helicase activity

single-stranded DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

four-way junction helicase activity

single-stranded DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity [inference]

DNA helicase activity [inference]

four-way junction helicase activity

single-stranded DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

four-way junction helicase activity

single-stranded DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

helicase

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
hydrolase activity
nucleotide binding

Displaying **all 9** entries
InterPro
C2 domain superfamily
DEAD/DEAH box helicase domain
Helicase superfamily 1/2, ATP-binding domain
Helicase, C-terminal domain-like
Immunoglobulin E-set
P-loop containing nucleoside triphosphate hydrolase
Sec63 domain
Winged helix DNA-binding domain superfamily
Winged helix-like DNA-binding domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060308	autosomal recessive intellectual developmental disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	10973	Xenbase:XB-GENE-6095530
Mus musculus	77987		MOUSE00900
Rattus norvegicus	309887		RATNO21416
Pan troglodytes	462898		PANTR38761
Canis lupus familiaris	475008		CANLF03017
Bos taurus	538416		BOVIN35632
Macaca mulatta	695429		MACMU35563
Monodelphis domestica	100020863		MONDO12647
Equus caballus	100066202		HORSE01308
Ornithorhynchus anatinus	100075002		ORNAN10862

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OrthoDB (Group)

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Acknowledgements