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Guidelines

MIRAGE

argininosuccinate lyase

Summary

Gene Symbol

Asl

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

109900

PubChem

109900

Alliance of Genome Resources

MGI:88084

Annotation

Keyword

Acetylation
Arginine biosynthesis
Lyase
Reference proteome
Urea cycle

Proteins

Displaying 1 entry
UniProt	Protein Name
Q91YI0	Arginosuccinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

1

2

3

4

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GO Term	Evidence Code	PMID
urea cycle	ISO
urea cycle	IEA
argininosuccinate metabolic process	ISO
liver development	ISO
amino acid metabolic process	IMP	12559843

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

urea cycle

amide metabolic process [inference]

glutamate metabolic process [inference]

ammonia assimilation cycle

urea metabolic process [inference]

urea cycle

amide biosynthetic process [inference]

urea cycle

nitrogen cycle metabolic process [inference]

urea metabolic process [inference]

urea cycle

organonitrogen compound metabolic process [inference]

amino acid metabolic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid metabolic process [inference]

argininosuccinate metabolic process

ornithine metabolic process [inference]

arginine biosynthetic process via ornithine

glutamine family amino acid metabolic process [inference]

arginine metabolic process

arginine biosynthetic process

arginine biosynthetic process via ornithine

glutamate metabolic process [inference]

ammonia assimilation cycle

glutamine metabolic process [inference]

ammonia assimilation cycle

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

cellular modified amino acid metabolic process [inference]

argininosuccinate metabolic process

urea metabolic process [inference]

urea cycle

organonitrogen compound biosynthetic process [inference]

urea cycle

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

urea cycle

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

organonitrogen compound biosynthetic process [inference]

urea cycle

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid metabolic process [inference]

argininosuccinate metabolic process

ornithine metabolic process [inference]

arginine biosynthetic process via ornithine

glutamine family amino acid metabolic process [inference]

arginine metabolic process

arginine biosynthetic process

arginine biosynthetic process via ornithine

glutamate metabolic process [inference]

ammonia assimilation cycle

glutamine metabolic process [inference]

ammonia assimilation cycle

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

ammonia assimilation cycle

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

tricarboxylic acid metabolic process [inference]

argininosuccinate metabolic process

cellular modified amino acid metabolic process [inference]

argininosuccinate metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

urea cycle

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

urea cycle

primary metabolic process [inference]

amino acid metabolic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid metabolic process [inference]

argininosuccinate metabolic process

ornithine metabolic process [inference]

arginine biosynthetic process via ornithine

glutamine family amino acid metabolic process [inference]

arginine metabolic process

arginine biosynthetic process

arginine biosynthetic process via ornithine

glutamate metabolic process [inference]

ammonia assimilation cycle

glutamine metabolic process [inference]

ammonia assimilation cycle

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid metabolic process [inference]

argininosuccinate metabolic process

ornithine metabolic process [inference]

arginine biosynthetic process via ornithine

glutamine family amino acid metabolic process [inference]

arginine metabolic process

arginine biosynthetic process

arginine biosynthetic process via ornithine

glutamate metabolic process [inference]

ammonia assimilation cycle

glutamine metabolic process [inference]

ammonia assimilation cycle

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

ammonia assimilation cycle

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

tricarboxylic acid metabolic process [inference]

argininosuccinate metabolic process

urea metabolic process [inference]

urea cycle

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid metabolic process [inference]

argininosuccinate metabolic process

ornithine metabolic process [inference]

arginine biosynthetic process via ornithine

glutamine family amino acid metabolic process [inference]

arginine metabolic process

arginine biosynthetic process

arginine biosynthetic process via ornithine

glutamate metabolic process [inference]

ammonia assimilation cycle

glutamine metabolic process [inference]

ammonia assimilation cycle

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

ammonia assimilation cycle

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

tricarboxylic acid metabolic process [inference]

argininosuccinate metabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid metabolic process [inference]

argininosuccinate metabolic process

ornithine metabolic process [inference]

arginine biosynthetic process via ornithine

glutamine family amino acid metabolic process [inference]

arginine metabolic process

arginine biosynthetic process

arginine biosynthetic process via ornithine

glutamate metabolic process [inference]

ammonia assimilation cycle

glutamine metabolic process [inference]

ammonia assimilation cycle

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

cellular modified amino acid metabolic process [inference]

argininosuccinate metabolic process

urea metabolic process [inference]

urea cycle

organonitrogen compound biosynthetic process [inference]

urea cycle

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

organonitrogen compound biosynthetic process [inference]

urea cycle

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid metabolic process [inference]

argininosuccinate metabolic process

ornithine metabolic process [inference]

arginine biosynthetic process via ornithine

glutamine family amino acid metabolic process [inference]

arginine metabolic process

arginine biosynthetic process

arginine biosynthetic process via ornithine

glutamate metabolic process [inference]

ammonia assimilation cycle

glutamine metabolic process [inference]

ammonia assimilation cycle

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

ammonia assimilation cycle

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

tricarboxylic acid metabolic process [inference]

argininosuccinate metabolic process

cellular modified amino acid metabolic process [inference]

argininosuccinate metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

urea cycle

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

arginine biosynthetic process

arginine biosynthetic process via ornithine

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

urea cycle

multicellular organismal process [inference]

behavior [inference]

locomotory behavior

post-embryonic development

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

liver development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular nitrogen homeostasis [inference]

nitrogen utilization [inference]

ammonia assimilation cycle

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular nitrogen homeostasis [inference]

nitrogen utilization [inference]

ammonia assimilation cycle

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

nitrogen utilization [inference]

ammonia assimilation cycle

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nitric oxide metabolic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

regulation of nitric oxide biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of nitric oxide biosynthetic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrial outer membrane	ISO
cytosol	IBA
neuronal cell body	ISO
perikaryon	ISO
perinuclear region of cytoplasm	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

cell body fiber

perikaryon

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 6 in total

1

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GO Term	Evidence Code	PMID
argininosuccinate lyase activity	ISS
argininosuccinate lyase activity	ISO
argininosuccinate lyase activity	IBA
protein binding	IPI	22081021
identical protein binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-nitrogen lyase activity [inference]

amidine-lyase activity [inference]

argininosuccinate lyase activity

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Lyase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 4** entries
Gene Ontology
arginine biosynthetic process via ornithine
argininosuccinate lyase activity
catalytic activity
lyase activity

Displaying **all 7** entries
InterPro
Argininosuccinate lyase, C-terminal
Argininosuccinate lyase
Fumarase/histidase, N-terminal
Fumarate lyase family
Fumarate lyase, N-terminal
Fumarate lyase, conserved site
L-Aspartase-like

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14755	argininosuccinic aciduria	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026