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cleavage and polyadenylation specific factor 6

Summary

Gene Symbol

CPSF6

Organism

Homo sapiens (human)

External Links

NCBI Gene

11052

PubChem

11052

Alliance of Genome Resources

HGNC:13871

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Direct protein sequencing
Methylation
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
mRNA processing

Proteins

Displaying 1 entry
UniProt	Protein Name
Q16630	Cleavage and polyadenylation specificity factor 68 kDa subunit Cleavage factor Im complex 68 kDa subunit Pre-mRNA cleavage factor Im 68 kDa subunit Protein HPBRII-4/7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
mRNA alternative polyadenylation	IMP	20695905 23187700 29276085
mRNA alternative polyadenylation	IBA
co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	IDA	29276085

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing

mRNA 3'-end processing

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization

protein heterotetramerization

protein heterooligomerization [inference]

protein heterotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization

protein heterotetramerization

protein heterooligomerization [inference]

protein heterotetramerization

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of nucleobase-containing compound transport [inference]

positive regulation of nucleobase-containing compound transport [inference]

positive regulation of RNA export from nucleus

regulation of RNA export from nucleus [inference]

positive regulation of RNA export from nucleus

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of nucleocytoplasmic transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of RNA export from nucleus [inference]

positive regulation of RNA export from nucleus

positive regulation of transport [inference]

positive regulation of nucleobase-containing compound transport [inference]

positive regulation of RNA export from nucleus

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of nucleocytoplasmic transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of RNA export from nucleus [inference]

positive regulation of RNA export from nucleus

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

positive regulation of transport [inference]

positive regulation of nucleobase-containing compound transport [inference]

positive regulation of RNA export from nucleus

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of nucleocytoplasmic transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of RNA export from nucleus

regulation of RNA export from nucleus [inference]

positive regulation of RNA export from nucleus

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	19864460 20695905 30916345
nucleoplasm	TAS
nucleoplasm	IDA	17267687
perichromatin fibrils	IDA	17267687
cytoplasm	IDA	19864460 30916345

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

mRNA cleavage factor complex

mRNA cleavage and polyadenylation specificity factor complex

ribonucleoprotein complex

cellular anatomical entity [inference]

nuclear body [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
RNA binding	IDA	15169763
RNA binding	HDA	22658674 22681889
mRNA binding	IDA	21295486
mRNA binding	IBA
protein binding	IPI	14561889 15169763 16189514 19447967 19864460 21295486 22960638 25416956 26496610 28514442 29276085 29507755 30916345 31465518 32296183 33961781 35177536 35271311 39251607

GO Hierarchy

molecular function

binding [inference]

protein binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding [inference]

ribosomal large subunit binding

exon-exon junction complex binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

mRNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cleavage and polyadenylation specificity factor

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
mRNA alternative polyadenylation

Displaying **all 4** entries
InterPro
CPSF6/7 family
Nucleotide-binding alpha-beta plait domain superfamily
RNA recognition motif domain
RNA-binding domain superfamily

Ortholog

Displaying entries **71 - 78** of 78 in total

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Species	Gene ID	Orthologous MAtrix
Strigops habroptila	115605369	STRHB21822
Corvus moneduloides	116442370	CORMO20595
Chelonoidis abingdonii	116834450	CHEAB16507
Rhinolophus ferrumequinum	117028216	RHIFE08954
Scophthalmus maximus	118290858	SCOMX21182
Balaenoptera musculus	118901582	BALMU03989
Canis lupus familiaris	119876134	CANLF01410
Panthera leo	122224816	PANLE18141