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Guidelines

MIRAGE

DExD-box helicase 52

Summary

Gene Symbol

DDX52

Organism

Homo sapiens (human)

External Links

NCBI Gene

11056

PubChem

11056

Alliance of Genome Resources

HGNC:20038

JoGo

DDX52

TogoVar

DDX52

Annotation

Keyword

3D-structure
Acetylation
Helicase
Nucleus
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B3KM65	ATP-dependent RNA helicase ROK1-like DEAD box protein 52
Q9Y2R4	ATP-dependent RNA helicase ROK1-like DEAD box protein 52

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
maturation of SSU-rRNA	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing [inference]

maturation of SSU-rRNA

ncRNA processing [inference]

rRNA processing [inference]

maturation of SSU-rRNA

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleoplasm	TAS
nucleolus	IEA
membrane	HDA	19946888

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
RNA helicase activity	IEA
ATP binding	IEA
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity [inference]

RNA helicase activity

catalytic activity, acting on RNA [inference]

RNA helicase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity [inference]

RNA helicase activity

ATP-dependent activity, acting on RNA [inference]

RNA helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

helicase

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
hydrolase activity
maturation of SSU-rRNA
nucleotide binding

Displaying **all 5** entries
InterPro
DEAD/DEAH box helicase domain
Helicase superfamily 1/2, ATP-binding domain
Helicase, C-terminal domain-like
P-loop containing nucleoside triphosphate hydrolase
RNA helicase, DEAD-box type, Q motif

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026